Expression of plasma membrane calcium ATPases confers Ca²⁺/H⁺ exchange in rodent synaptic vesicles.

ABSTRACT: Ca²⁺ transport into synaptic vesicles (SVs) at the presynaptic terminals has been proposed to be an important process for regulating presynaptic [Ca²⁺] during stimulation as well as at rest. However, the molecular identity of the transport system remains elusive. Previous studies have demonstrated that isolated SVs exhibit two distinct Ca²⁺ transport systems depending on extra-vesicular (cytosolic) pH; one is mediated by a high affinity Ca²⁺ transporter which is active at neutral pH and the other is mediated by a low affinity Ca²⁺/H⁺ antiporter which is maximally active at alkaline pH of 8.5. In addition, synaptic vesicle glycoprotein 2 s (SV2s), a major SV component, have been proposed to contribute to Ca²⁺ clear

SUBMITTER: Ono Y 

PROVIDER: S-EPMC6414521 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature