Mast cells regulate CD4⁺ T-cell differentiation in the absence of antigen presentation.

ABSTRACT:

Background

Given their unique capacity for antigen uptake, processing, and presentation, antigen-presenting cells (APCs) are critical for initiating and regulating innate and adaptive immune responses. We have previously shown the role of nicotinamide adenine dinucleotide (NAD⁺) in T-cell differentiation independently of the cytokine milieu, whereas the precise mechanisms remained unknown.

Objective

The objective of this study is to further dissect the mechanism of actions of NAD⁺ and determine the effect of APCs on NAD⁺-mediated T-cell activation.

Methods

Isolated dendritic cells and bone marrow-derived mast cells (MCs) were used to characterize the mechanisms of action of NAD⁺ on CD4⁺ T-cell fate in vitro. Furth

SUBMITTER: Rodriguez Cetina Biefer H 

PROVIDER: S-EPMC6454881 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature