Transverse relaxation rates of pulmonary dissolved-phase Hyperpolarized ¹²⁹ Xe as a biomarker of lung injury in idiopathic pulmonary fibrosis.

ABSTRACT:

Purpose

The MR properties (chemical shifts and R2∗ decay rates) of dissolved-phase hyperpolarized (HP) ¹²⁹ Xe are confounded by the large magnetic field inhomogeneity present in the lung. This work improves measurements of these properties using a model-based image reconstruction to characterize the R2∗ decay rates of dissolved-phase HP ¹²⁹ Xe in healthy subjects and patients with idiopathic pulmonary fibrosis (IPF).

Methods

Whole-lung MRS and 3D radial MRI with four gradient echoes were performed after inhalation of HP ¹²⁹ Xe in healthy subjects and patients with IPF. A model-based image reconstruction formulated as a regularized optimization problem was solved iteratively to measure regional signal intensity in the gas, barrier, and red blo

SUBMITTER: Kammerman J 

PROVIDER: S-EPMC7329592 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature