Intra-individual dynamic comparison of ¹⁸F-PSMA-11 and ⁶⁸Ga-PSMA-11 in LNCaP xenograft bearing mice.

ABSTRACT: Recently, a ¹⁸F-labeled derivative of the widely used ⁶⁸Ga-PSMA-11 was developed for PET imaging of prostate cancer. Although ¹⁸F-PSMA-11 has already been evaluated in a Phase I and Phase II clinical trial, preclinical evaluation of this radiotracer is important for further understanding its dynamic behavior. Saturation binding experiments were conducted by incubation of LNCaP cells with ¹⁸F-PSMA-11 or ⁶⁸Ga-PSMA-11 for 1 h, followed by determination of the specific and aspecific binding. Mice bearing LNCaP or PC-3 xenografts each received ± 3.7 MBq ¹⁸F-PSMA-11 and ⁶⁸Ga-PSMA-11 followed by dynamic acquisition of 2.5 h as well as ± 15 MBq ¹⁸F-FDG followed by static acquisition at 1 h post injection (p.i.)

SUBMITTER: Piron S 

PROVIDER: S-EPMC7713063 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature