68 Ga-Labelled Tropane Analogues for the Visualization of the Dopaminergic System.
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ABSTRACT:
SUBMITTER: Haseli S
PROVIDER: S-EPMC7984292 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
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<sup>68</sup> Ga-Labelled Tropane Analogues for the Visualization of the Dopaminergic System.
Häseli Sascha S Holy Marion M Joksch Markus M Bergner Carina C Wree Andreas A Kurth Jens J Cankaya Aylin A Piel Markus M Krause Bernd J BJ Sitte Harald H HH Rösch Frank F
ChemMedChem 20201210 5
The development of radiometal-labelled pharmaceuticals for neuroimaging could offer great potential due to easier handling during labelling and availability through radionuclide generator systems. Nonetheless, to date, no such tracers are available for positron emission tomography, primarily owing to the challenge of crossing the blood-brain barrier (BBB) and loss of affinity through chelator attachment. We have prepared a variety of <sup>68</sup> Ga-labelled phenyltropanes showing that, through ...[more]
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