Impact of total variation regularized expectation maximization reconstruction on the image quality of ⁶⁸Ga-PSMA PET: a phantom and patient study.

ABSTRACT:

Objectives

To investigate the impact of total variation regularized expectation maximization (TVREM) reconstruction on the image quality of ⁶⁸Ga-PSMA-11 PET/CT using phantom and patient data.

Methods

Images of a phantom with small hot sphere inserts and 20 prostate cancer patients were acquired with a digital PET/CT using list-mode and reconstructed with ordered subset expectation maximization (OSEM) and TVREM with seven penalisation factors between 0.01 and 0.42 for 2 and 3 minutes-per-bed (m/b) acquisition. The contrast recovery (CR) and background variability (BV) of the phantom, image noise of the liver, and SUV_max of the lesions were measured. Qualitative image quality was scored by two radiologists using a 5-point scale (1-poor, 5-excellent).

R

SUBMITTER: Yang FJ 

PROVIDER: S-EPMC8010539 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature