Shorter Chain Triglycerides Are Negatively Associated with Symptom Improvement in Schizophrenia.

ABSTRACT: Schizophrenia is a serious mental disorder requiring lifelong treatment. While medications are available that are effective in treating some patients, individual treatment responses can vary, with some patients exhibiting resistance to one or multiple drugs. Currently, little is known about the causes of the difference in treatment response observed among individuals with schizophrenia, and satisfactory markers of poor response are not available for clinical practice. Here, we studied the changes in the levels of 322 blood plasma lipids between two time points assessed in 92 individuals diagnosed with schizophrenia during their inpatient treatment and their association with the extent of symptom improvement. We found 20 triglyceride species increased in individuals with the least improveme

SUBMITTER: Tkachev A 

PROVIDER: S-EPMC8151512 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature