External Validation of Two Nomograms Developed for ⁶⁸Ga-PSMA-11 Applied to the Prostate-specific Membrane Antigen Tracer ¹⁸F-DCFPyl: Is Prediction of the Optimal Timing of Salvage Therapy Feasible?

ABSTRACT: Two nomograms have been developed to predict the outcome of positron emission tomography (PET)/computed tomography (CT) imaging with⁶⁸Ga-labeled ligands for prostate-specific membrane antigen (⁶⁸Ga-PSMA) for patients with rising prostate-specific antigen after radical prostatectomy (RP). These nomograms quantify the ability of PSMA PET/CT to detect prostate cancer recurrences, and therefore provide critical information in determining the optimal timing for PSMA PET/CT in guiding salvage therapies. We validated the ability of these nomograms to accurately predict PET/CT outcome using another ligand tracer, ¹⁸F-DCFPyL. The external validation cohort consisted of 157 men from the Prostate Cancer Network Netherlands who underwent ¹⁸F-DCFPyL PET/CT to

SUBMITTER: Luiting HB 

PROVIDER: S-EPMC8317859 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature