Does quantification of [¹¹C]meta-hydroxyephedrine and [¹³N]ammonia kinetics improve risk stratification in ischemic cardiomyopathy.

ABSTRACT:

Background

In ischemic cardiomyopathy patients, cardiac sympathetic nervous system dysfunction is a predictor of sudden cardiac arrest (SCA). This study compared abnormal innervation and perfusion measured by [¹¹C]meta-hydroxyephedrine (HED) vs [¹³N]ammonia (NH₃), conventional uptake vs parametric tracer analysis, and their SCA risk discrimination.

Methods

This is a sub-study analysis of the prospective PAREPET trial, which followed ischemic cardiomyopathy patients with reduced left ventricular ejection fraction (LVEF ≤ 35%) for events of SCA. Using n = 174 paired dynamic HED and NH₃ positron emission tomography (PET) scans, regional defect scores (%LV extent × severity) were calculated using HED and NH₃ uptake, as well

SUBMITTER: Wang JZ 

PROVIDER: S-EPMC8807773 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature