Transcriptome Profiling of Porcine Naive, Intermediate and Terminally Differentiated CD8⁺ T Cells.

ABSTRACT: The pig has the potential to become a leading research model for human diseases, pharmacological and transplantation studies. Since there are many similarities between humans and pigs, especially concerning anatomy, physiology and metabolism, there is necessity for a better understanding of the porcine immune system. In adaptive immunity, cytotoxic T lymphocytes (CTLs) are essential for host defense. However, most data on CTLs come from studies in mice, non-human primates and humans, while detailed information about porcine CD8⁺ CTLs is still sparse. Aim of this study was to analyze transcriptomes of three subsets of porcine CD8β⁺ T-cell subsets by using next-generation sequencing technology. Specifically, we described transcriptional profiles of subsets defined by th

SUBMITTER: Lagumdzic E 

PROVIDER: S-EPMC8900158 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature