Dataset Information

Network-wise concordance of multimodal neuroimaging features across the Alzheimer's disease continuum.

ABSTRACT:

Background

Concordance between cortical atrophy and cortical glucose hypometabolism within distributed brain networks was evaluated among cerebrospinal fluid (CSF) biomarker-defined amyloid/tau/neurodegeneration (A/T/N) groups.

Method

We computed correlations between cortical thickness and fluorodeoxyglucose metabolism within 12 functional brain networks. Differences among A/T/N groups (biomarker normal [BN], Alzheimer's disease [AD] continuum, suspected non-AD pathologic change [SNAP]) in network concordance and relationships to longitudinal change in cognition were assessed.

Results

Network-wise markers of concordance distinguish SNAP subjects from BN subjects within the posterior multimodal and language networks. AD-continuum subjects showed increased concordance in 9/12 networks assessed compared to BN subjects, as well as widespread atrophy and hypometabolism. Baseline network concordance was associated with longitudinal change in a composite memory variable in both SNAP and AD-continuum subjects.

Conclusions

Our novel study investigates the interrelationships between atrophy and hypometabolism across brain networks in A/T/N groups, helping disentangle the structure-function relationships that contribute to both clinical outcomes and diagnostic uncertainty in AD.

SUBMITTER: Stocks J

PROVIDER: S-EPMC9043119 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Network-wise concordance of multimodal neuroimaging features across the Alzheimer's disease continuum.

Stocks Jane J Popuri Karteek K Heywood Ashley A Tosun Duygu D Alpert Kate K Beg Mirza Faisal MF Rosen Howard H Wang Lei L

Alzheimer's & dementia (Amsterdam, Netherlands) 20220426 1

<h4>Background</h4>Concordance between cortical atrophy and cortical glucose hypometabolism within distributed brain networks was evaluated among cerebrospinal fluid (CSF) biomarker-defined amyloid/tau/neurodegeneration (A/T/N) groups.<h4>Method</h4>We computed correlations between cortical thickness and fluorodeoxyglucose metabolism within 12 functional brain networks. Differences among A/T/N groups (biomarker normal [BN], Alzheimer's disease [AD] continuum, suspected non-AD pathologic change [ ...[more]

PMID: 35496375

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Dataset Information

Network-wise concordance of multimodal neuroimaging features across the Alzheimer's disease continuum.

Background

Method

Results

Conclusions

Publications

Network-wise concordance of multimodal neuroimaging features across the Alzheimer's disease continuum.

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