Application of a Novel ⁶⁸Ga-HER2 Affibody PET/CT Imaging in Breast Cancer Patients.

ABSTRACT:

Background

Breast cancer is a heterogeneous disease, and the human epidermal growth factor receptor 2 (HER2) expression may vary considerably between primary and metastatic lesions, or even within a single lesion. Repeated biopsies cannot always be performed. In this feasibility trial, we assessed whether a novel ⁶⁸Ga-NOTA-MAL-MZHER2 (⁶⁸Ga-HER2) affibody PET/CT could determine the HER2 status of each lesion if there was a clinical need for it.

Methods

⁶⁸Ga-HER2 affibody PET/CT was performed in breast cancer patients if HER2 status remained unclear after standard examinations (including bone scan, ¹⁸F-FDG PET/CT, CT, and feasible biopsy). All available images for each patient were evaluated through an independent review of two commi

SUBMITTER: Miao H 

PROVIDER: S-EPMC9195516 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature