The metabolism of 1,25(OH)₂D₃ in clinical and experimental kidney disease.

ABSTRACT: Chronic kidney disease (CKD) results in calcitriol deficiency and altered vitamin D metabolism. The objective of this study was to assess the 24-hydroxylation-mediated metabolism of 25(OH)D₃ and 1,25(OH)₂D₃ in a cross-sectional analysis of participants with a range of kidney function assessed by precise measured GFR (mGFR) (N = 143) and in rats with the induction and progression of experimental kidney disease. Vitamin D metabolites were assessed with LC-MS/MS. Circulating measures of 24-hydroxylation of 25(OH)D₃ (24,25(OH)₂D₃:25(OH)D₃) precisely decreased according to mGFR in humans and progressively in rats with developing CKD. In contrast, the 1,24,25(OH)3D3: 1,25(OH)₂D₃ vitamin D metabolit

SUBMITTER: Turner ME 

PROVIDER: S-EPMC9240002 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature