Comparison of integrin α_vβ₃ expression with ⁶⁸Ga-NODAGA-RGD PET/CT and glucose metabolism with ¹⁸F-FDG PET/CT in esophageal or gastroesophageal junction cancers.

ABSTRACT:

Background

The primary aims of this study were to compare in patients with esophageal or esophagogastric junction cancers the potential of ⁶⁸Ga-NODAGA-RGD PET/CT with that of ¹⁸F-FDG PET/CT regarding tumoral uptake and distribution, as well as histopathologic examination.

Methods

Ten ⁶⁸Ga-NODAGA-RGD and ten ¹⁸F-FDG PET/CT were performed in nine prospectively included participants (1 woman; aged 58 ± 8.4 y, range 40-69 y). Maximum SUV (SUV_max) and metabolic tumor volumes (MTV) were calculated. The Mann-Whitney U test and Spearman correlation analysis (ρ) were used.

Results

⁶⁸Ga-NODAGA-RGD PET/CT detected positive uptake in 10 primary sites (8 for primary tumors and 2 for local relapse suspicion), 6 lymph

SUBMITTER: Dietz M 

PROVIDER: S-EPMC9889587 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature