Thiol-Activated 1,2,4-Thiadiazolidin-3,5-diones Release Hydrogen Sulfide through a Carbonyl-Sulfide-Dependent Pathway.

ABSTRACT: Recent efforts have expanded the development of small molecule donors that release the important biological signaling molecule hydrogen sulfide (H₂S). Previous work on 1,2,4-thiadiazolidin-3,5-diones (TDZNs) reported that these compounds release H₂S directly, albeit inefficiently. However, TDZNs showed promising efficacy in H₂S-mediated relaxation in ex vivo aortic ring relaxation models. Here, we show that TDZNs release carbonyl sulfide (COS) efficiently, which can be converted to H₂S by the enzyme carbonic anhydrase (CA) rather than releasing H₂S directly as previously reported.

SUBMITTER: Smith HM 

PROVIDER: S-EPMC9893878 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature