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MetabolomicsNeuronal Hyperactivity due to Loss of Inhibitory Tone in APOE4 Mice Lacking Alzheimer’s Disease-like Pathology
Metabolite profiling was performed on metabolites extracted from the entorhinal cortex and primary visual cortex of 14-15 month old APOE3/3, APOE3/4 and APOE4/4 mice. Metabolites were run on a TOF Mass Spectrometer using an ANP column. Initial analysis was done in an untargeted manner, and processin...
2017-09-05 | MTBLS530 | MetaboLights
MetabolomicsWT neurons treated with APOE3/3 and APOE4/4 ACM
Not available
ORGANISM(S): Mus musculus 
ST001820 | MetabolomicsWorkbench
MetabolomicsEC and PVC from 14-15 month-old APOE3/3, APOE3/4 and APOE4/4 mice
Not available
ORGANISM(S): Mus musculus 
ST001819 | MetabolomicsWorkbench
ProteomicsProteomics of APOE3 and APOE4 BMDMs
The protein expression differences of APOE3 and APOE4 bone marrow-derived macrophages.
ORGANISM(S): Mus Musculus 
2025-01-10 | PXD059706 |
ProteomicsAPOE4 cell-specific mechanisms underlying cerebrovascular disorder precede neuronal and synaptic dysfunction and cognitive deficits in mice
Apolipoprotein E4 (APOE4), the main susceptibly gene for Alzheimer’s disease1–5, exerts cerebrovascular toxicity6 leading to blood-brain barrier (BBB) breakdown in humans7–9 and APOE4 transgenic mice10–13. Moreover, an early BBB dysfunction predicts cognitive decline in humans7. However, the compre...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-23 | PXD029230 | Pride
Phosphoproteome Alzheimer’s disease Signaling networks Single cell rna-seq Apoe4 Bbb breakdown Interactome Blood-brain barrier 
ProteomicsLC-MS/MS of HNE-apoE3 and HNE-apoE4
The overall goal of our study is to understand the effect of HNE modification on the structure and function of apolipoprotein E3 (apoE3) and apoE4, which play a critical role in brain cholesterol homeostasis. Immunoblots indicated HNE modification of recombinant apoE3 and apoE4 with a major band at ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD038105 | Pride
Hne Apoe3 Apoe4 
ProteomicsLysosomal proteomics reveals mechanisms of neuronal apoE4 - 2 associated lysosomal dysfunction
The E4 variant of APOE is the primary risk factor for Alzheimer’s Disease. While APOE is primarily expressed by astrocytes, early AD pathology appears predominantly in neurons, including endosomal abnormalities and mitochondrial dysfunction. Lysosomes are poised at the convergence point between thes...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD044942 | Pride
Lgals3bp Apms Mass spectrometry Apoe 4 Alzheimer’s disease Lysosomes 
ProteomicsLow-dose Copper exposure exacerbates depression-like behavior in ApoE4 transgenic mice
Depression is one of the most common neuropsychiatric disorders. Although the pathogenesis of depression is still unknown, environmental risk factors and genetics are implicated. Copper (Cu), a cofactor of multiple enzymes, is involved in regulating depression-related processes. Depressed patients c...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022422 | Pride
Depression  proteomics  copper (cu)  apoe4 
TranscriptomicsDifferential gene expression in APOE3 and APOE4 gene targeted replacement mice
The aim of the study was to investigate hepatic gene expression profiles differentially regulated by the APOE genotype in gene targeted replacement mice. The APOE4 genotype is associated with increased mortality in the elderly and is an independent risk factor for age-dependent chronic diseases. How...
ORGANISM(S): Mus musculus 
2012-12-15 | E-GEOD-42930 | biostudies-arrayexpress
ProteomicsApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes
Recent developments in genome sequencing have expanded the knowledge of genetic factors associated with late-onset Alzheimer’s disease (AD). Among them, genetic variant e4 of the APOE gene (ApoE4) confers the greatest disease risk. Dysregulated glucose metabolism is an early pathological feature of ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-12 | PXD045298 | Pride
Mitophagy Lysosomal cholesterol accumulation Apoe4 Glucose metabolism Human astrocytes 
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