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MetabolomicsPP2Cm Dysregulation Is Associated with Impaired BCAA Catabolism and cGAS-STING Activation in Diabetic Kidney Disease
Background and Aims:Branched-chain amino acids (BCAAs) are increasingly implicated in diabetic kidney disease (DKD), yet the role of protein phosphatase 2C mitochondrial (PP2Cm), encoded by PPM1K and regulating BCAA catabolism through the branched-chain α-ketoacid dehydrogenase (BCKDH) complex, rema...
2026-10-09 | MTBLS15967 | MetaboLights
MetabolomicsLily polysaccharides alleviate colitis through the microbiota/N8AS/cGAS-STING signaling axis

With the rising incidence of IBD and limitations of current therapies, novel strategies are urgently needed. Recent studies have highlighted natural products in colitis treatment. Here, we investigated the therapeutic effects and mechanisms of lily polysaccharides (LP) in DSS-induced ulcerative c...

2025-09-29 | MTBLS13064 | MetaboLights
GenomicsCK1α suppresses autoimmunity by restraining the cGAS-STING signaling
CK1α suppresses autoimmunity by restraining the cGAS-STING signaling
PRJNA940749 | ENA
ProteomicsIntracellular bacteria engage a novel STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signaling
The innate immune system is crucial for eventual control of infections, but may also contribute to pathology. Listeria monocytogenes is an intracellular gram-positive bacteria and a major cause of food-borne disease. However, important knowledge on the interactions between L. monocytogenes and the i...
ORGANISM(S): Mus musculus (Mouse) 
2018-12-20 | PXD012135 | Pride
Phosphoproteomics Sting Cgas Intracellular bacteria Nucleic acid sensing 
GenomicsAn HIV protein mediates immune evasion by targeting cGAS–STING signaling
An HIV protein mediates immune evasion by targeting cGAS–STING signaling
PRJNA782882 | ENA
GenomicsUrolithin A is a potent modulator of cGAS-Sting signaling pathway
Urolithin A is a potent modulator of cGAS-Sting signaling pathway
PRJNA930416 | ENA
GenomicsRiluzole Enhancing anti-PD-1 Efficacy by Activating cGAS/STING Signaling
Riluzole Enhancing anti-PD-1 Efficacy by Activating cGAS/STING Signaling
PRJNA1055952 | ENA
ProteomicsThe Kinase CK1a coordinates Initiation and Termination of the cGAS-STING Pathway
The cGAS-STING pathway is an evolutionarily conserved antimicrobial defense mechanism that senses cytosolic DNA to trigger innate immune responses. cGAS and STING play dual roles in tumorigenesis, promoting antitumor immunity and cell death while fueling tumor growth and metastasis. However, the mec...
ORGANISM(S): Homo sapiens (Human) 
2026-09-10 | PXD063855 | Pride
Biotin Apex Lc-ms Cgas/ting Ap-ms Ck1-alpha 
ProteomicsThe Kinase CK1a coordinates Initiation and Termination of the cGAS-STING Pathway. Comparative proteomic analysis of CK1a partners.
The cGAS-STING pathway is an evolutionarily conserved antimicrobial defense mechanism that senses cytosolic DNA to trigger innate immune responses. cGAS and STING play dual roles in tumorigenesis, promoting antitumor immunity and cell death while fueling tumor growth and metastasis. However, the mec...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD066276 | Pride
Innate immunity Sting Cgas Csnk1a1 Dna sensing 
UnknownMicroglial cGAS-STING signaling underlies glaucoma pathogenesis.
Not available
S-EPMC11388346 | biostudies-literature
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