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TranscriptomicsTranscription profiling of four mouse bone marrow hematopoietic stem cells (HSC) early B lineage stages(MLP, CLP, Fr.A, Fr.B) to identify coordinately regulated gene as cells progress down the B cell development pathway
Differentiation from hematopoietic stem cells (HSC) to early B-lineage cells proceeds through a series of intermediate stages, during which cells are thought to become progressively more restricted in their developmental potential. RNAs were prepared from four early B lineage stages(MLP, CLP, Fr.A, ...
ORGANISM(S): Mus musculus 
2006-12-16 | E-MEXP-559 | biostudies-arrayexpress
ProteomicsFunction of clpF in the clp protease complex
The plant plastid Clp machinery comprises a hetero-oligomeric ClpPRT proteolytic core, ATP-dependent ClpC,D chaperones and an adaptor protein, ClpS1. ClpS1 directs a subset of substrates to the Clp protease-chaperone complex for degradation, but substrate recognition and delivery mechanisms are unkn...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-04-09 | PXD002186 | Pride
Lc-msms Plant cell Arabidopsis thaliana Coip Clp complex Chloroplast Stroma 
TranscriptomicsThe basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor
Innate lymphoid cells (ILCs) are recently identified lymphocytes that limit infection and promote tissue repair at mucosal surfaces. However, the pathways underlying ILC development remain unclear. Here we show that the transcription factor NFIL3 directs the development of a committed bone marrow pr...
ORGANISM(S): Mus musculus 
2014-10-16 | E-GEOD-62337 | biostudies-arrayexpress
ProteomicsTime-resolved inducible knock-down of Clp protease subunits in tobacco identifies putative protease substrates
The Clp protease complex in plants is the one with the highest complexity through all life kingdoms. It is composed of 14 nuclear- and plastid-encoded subunits which are allocated in different rings across the complex. The proteolytic ring (P-ring; ClpP3-ClpP6) and non-proteolytic ring (R-ring; ClpR...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-02-22 | PXD008305 | Pride
Clp protease  chloroplast  protein degradation  protease substrate  nicotiana tabacum  inducible rnai  lc-msms  shotgun proteomics 
GenomicsMOUSE with CLP modeling
MOUSE with CLP modeling Raw sequence reads
PRJNA1330473 | ENA
TranscriptomicsTranscription profiling of rat liver samples from individuals subjected to burn injury or cecal ligation and puncture
The experimental design included three biological replicates for each of the three conditions: Sham-Sham, Sham-CLP and burn-CLP. Liver samples were collected from the rats and the total RNA was analyzed on a Affymetrix RAE230A chip. No technical replicates were included in the study
ORGANISM(S): Rattus norvegicus 
2007-11-03 | E-GEOD-1781 | biostudies-arrayexpress
GenomicsLacticaseibacillus paracasei strain:CLP-E2
Lacticaseibacillus paracasei CLP-E2 Genome sequencing
PRJNA798620 | ENA
TranscriptomicsMesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis
Expression data from Total RNA extracted from murine spleen. Sepsis was induced in C57Bl/6J mice by cecal ligation and puncture (CLP), followed 6 hours later by an intravenous injection of Mesenchymal Stem Cell (MSC) or saline. Twenty-eight hours after CLP, plasma, bronchoalveolar lavage (BAL) flui...
ORGANISM(S): Mus musculus 
2010-11-22 | E-GEOD-24357 | biostudies-arrayexpress
GenomicsLacticaseibacillus paracasei strain:CLP-E2
Lacticaseibacillus paracasei strain:CLP-E2 Genome sequencing
PRJNA816640 | ENA
TranscriptomicsExpression data from WT, HEB-KO and E2A-KO LY6D- CLP cells
The E-protein transcription factors E2A and HEB play important roles at several stages of hematopoiesis. However, the exact mechanism for theire action and the main targets in the LY6D negative common lymphoid progentior (CLP) compartment remains unknown. By adressing this question, we will gain imp...
ORGANISM(S): Mus musculus 
2011-11-22 | E-GEOD-27402 | biostudies-arrayexpress
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