complexity-based correction factor

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Lab affiliation

Professor of Pathology, Oncology, and Chemical and Biomolecular Engineering Director of Mass Spectrometry Core Facility, Center for Biomarker Discovery and Translation Johns Hopkins University 400 N. Broadway Street, Smith Building, Room 4011, Baltimore, MD 21231 (1)
Department of Chemical Sciences, University of Naples 'FedericoII', Naples, Italy; CEINGE scarl Advanced Biotechnology, Facility of Proteomics, Naples, Italy (1)
Department of Biology II and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München (1)

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New label free methods for protein relative quantification applied to the investigation of animal model of Huntington Disease.

Spectral Counts approaches (SpCs) are largely employed for the comparison of protein expression profiles in label free differential proteomics applications. Similarly, to other comparative methods, also SpCs based approaches require a normalization procedure before Fold Changes (FC) calculation. Her...

ORGANISM(S): Mus musculus (Mouse)

2020-08-18 | PXD017471 | Pride

The link between steady-state EEG and rs-fMRI metrics in healthy young adults: The effect of macrovascular correction.

Not available

S-EPMC12797145 | biostudies-literature

Transcriptome analysis of Geobacter sulfurreducens under multiple growth conditions

Investigation of comprehensive information about the transcripts (boundary, level, etc.) across the entire G. sulfurreducens genome in mulitple growth conditions, including in biofilm and on electrode. A five array study using total RNA recovered from two separate culture conditions of G. sulfurred...

ORGANISM(S): Geobacter sulfurreducens PCA

2010-07-01 | E-GEOD-22497 | biostudies-arrayexpress

Array CGH analysis of Oral Squamous Cell Carcinoma

Array Comparative Genomic Hybridization (CGH) profiling of Oral Sqaumaous Cell Carcinoma (OSCC) was performed to delineate candidate non-random chromosomal loci associated with clinico-pathological parameters. The array CGH hybridizations were performed for 60 OSCC samples with pooled gender matched...

ORGANISM(S): Homo sapiens

2011-03-11 | E-GEOD-23831 | biostudies-arrayexpress

Transcription profiling of liver, skeletal muscle and white adipose tissue from ApoE3L mice

Our aim was to investigate gene expression changes over time in liver of ApOE3*Leiden mice on a high-fat diet. Probesets were remapped and annotated into Entrez gene-ids using the custom MBNI CDF-file, version 9.0.1 - the GCRMA data generated

ORGANISM(S): Mus musculus

2010-07-28 | E-TABM-1039 | biostudies-arrayexpress

ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights

Adaptation of Bacillus subtilis carbon core metabolism to simultaneous nutrient limitation and osmotic challenge

Here, we investigated for the first time the systems-wide response of B. subtilis to different simultaneous stresses, i.e. nutrient limitation and high osmolarity. To address the anticipated complexity of the cellular response networks, we combined chemostat experiments under conditions of carbon li...

ORGANISM(S): Bacillus subtilis

2014-03-31 | E-GEOD-53333 | biostudies-arrayexpress

The association between metabolite concentrations and wellbeing in adults.

Not available

S-EPMC11868532 | biostudies-literature

Ubiquitome analysis of UHRF1 and UHRF2-deficient mESCs

The E3 ligase UHRF1 is an essential epigenetic cofactor for DNMT1 dependent maintenance DNA methylation, which provides a binding platform for DNMT1 by both cooperative binding of histones and hemi-methylated DNA as well as by ubiquitinating histone H3. Here, we conduct a comprehensive screen to ide...

ORGANISM(S): Mus musculus (Mouse)

2017-10-24 | PXD006593 | Pride

Ubiquitination Paf Mouse embryonic stem cells Uhrf

Integration analysis of three omics data using penalized regression methods: An application to bladder cancer (expression)

Omics data integration is becoming necessary to investigate the still unknown genomic mechanisms of complex diseases. During the integration process, many challenges arise such as data heterogeneity, the smaller number of individuals in comparison to the number of parameters, multicollinearity, and ...