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ProteomicsEndometrial gland impacts on stromal cell decidualization
Uterine glands and, by inference, their secretions impact uterine receptivity, blastocyst implantation, stromal cell decidualization, and placental development. Changes in gland function across the menstrual cycle are impacted by steroid hormones, estrogen and progesterone, as well as stroma-derived...
ORGANISM(S): Homo sapiens (Human) 
2023-10-11 | PXD034357 | Pride
Hormone Endometrium Decidualization Gland Pge2 Stroma 
GenomicsGenome-wide analysis of histone modifications in human endometrial stromal cells [ChIP-Seq]
Dramatic changes of gene expressions are known to occur in human endometrial stromal cells (ESC) during decidualization. The changes in gene expression are associated with changes of chromatin structure, which are regulated by epigenetic mechanisms such as histone modifications. Here, we investiga...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-57007 | biostudies-arrayexpress
TranscriptomicsEffect of the Conceptus on Global Gene Expression in the Mouse Uterus During Decidualization
Analysis of differences in gene expression in the mouse uterus during decidualization in the presence and absence of a conceptus. A deciduomal model previously shown to better mimick natural decidualization was used. The results reveal some, but very few, genes that are differentially expressed, wh...
ORGANISM(S): Mus musculus 
2011-11-20 | E-GEOD-25903 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model of decidulization and menstruation
A murine model that mimic the decidualization and regression observed in human was used to investigate the molecular mechanisms underlying the dynamic processes in endometrium. Ovariectomized mice were treated sequentially with steroid hormones and then, to induce decidualization, oil was injected i...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6359 | biostudies-arrayexpress
ProteomicsEndometrial extracellular vesicle decidualization
Proper decidualization is vital in preparation for a potential embryo receptivity, placentation, menstrual health and subsequent endometrial regeneration. Given the importance of extracellular vesicles (EVs) in intercellular communication, and recently in embryo implantation and indicators of menstr...
ORGANISM(S): Homo sapiens (Human) 
2021-11-17 | PXD026342 | Pride
Exosomes Endometrial Extracellular vesicles Decidualization 
TranscriptomicsThe coregulator, repressor of Estrogen Receptor Activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization.
Our findings establish a key role for the coregulator, Repressor of Estrogen receptor Activity (REA), in controlling the timing and magnitude of decidualization in human endometrial stromal cells in vitro and in the mouse uterus in vivo, and suggest that REA functions to synchronize uterine differen...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-42376 | biostudies-arrayexpress
TranscriptomicsTubal ectopic pregnancy as a model to identify endometrial genes and signaling pathways important in decidualization and regulated by local trophoblast
Gestation-matched endometrium was collected from women with ectopic pregnancy (EP) (n=11) and intrauterine pregnancies (IUP) (n=13). RNA was extracted from the tissue. In addition, tissues were prepared for histological analysis for degree of decidualization. We compared a) the samples from EP that ...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-MTAB-680 | biostudies-arrayexpress
GenomicsHDAC3 Regulates Transcriptional Networks Governing Decidualization
HDAC3 Regulates Transcriptional Networks Governing Decidualization
PRJNA1419596 | ENA
TranscriptomicsGenome-wide analysis of histone modifications in human endometrial stromal cells [RNA-Seq]
Dramatic changes of gene expressions are known to occur in human endometrial stromal cells (ESC) during decidualization. The changes in gene expression are associated with changes of chromatin structure, which are regulated by epigenetic mechanisms such as histone modifications. Here, we investiga...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-57009 | biostudies-arrayexpress
GenomicsEndometrial gland secretome maintains the homeostasis of decidualization
Endometrial gland secretome maintains the homeostasis of decidualization
PRJNA1297582 | ENA
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