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MetabolomicsQuantitative metabolomic analysis of changes in the lens and aqueous humor under development of age-related nuclear cataract

INTRODUCTION: Metabolites are essential for the proper functioning of the eye lens, they either enter the lens from the aqueous humor (AH), or are synthesized in the lens epithelium. Antioxidants, osmolytes and UV filters are especially important for the lens protection, and thei...

2022-11-07 | MTBLS740 | MetaboLights
ProteomicsSH2B1 Promotes Apoptosis in Diabetic Cataract via p38 MAPK Pathway
Diabetic patients face an increased risk of developing cataracts, with unclear mechanisms. Our study illuminates these mechanisms by identifying differentially expressed proteins in the lens anterior capsule of diabetic cataract (DC) and age-related cataract patients using quantitative proteomics. W...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059243 | Pride
Ophthalmology  protein interaction network  high-fat diet  diabetic cataract  cell culture Proteomics Oxidative stress  high-glucose environment  autophagy  epithelial–mesenchymal transition 
ProteomicsProteomic changes in lens of diabetic, age-related and post-vitrectomy cataract.
The focus of our research centers on exploring the proteome changes and corresponding signaling pathways involved in the development of diabetic cataract, age-related cataract and post-vitrectomy cataract, investigating aqueous humor, anterior capsule and lens human samples. Outstanding proteomic pr...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045557 | Pride
Cataract Aging Vitrectomy Diabetes Crystallin Cytoskeleton Lens Proteomics 
ProteomicsProteomic changes in anterior capsule of diabetic, age-related and post-vitrectomy cataract.
The focus of our research centers on exploring the proteome changes and corresponding signaling pathways involved in the development of diabetic cataract, age-related cataract and post-vitrectomy cataract, investigating aqueous humor, anterior capsule and lens human samples. Outstanding proteomic pr...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045547 | Pride
Anterior capsule Cataract Aging Vitrectomy Diabetes Crystallin Cytoskeleton Proteomics 
ProteomicsProteomic changes in aqueous humor of diabetic, age-related and post-vitrectomy cataract.
The focus of our research centers on exploring the proteome changes and corresponding signaling pathways involved in the development of diabetic cataract, age-related cataract and post-vitrectomy cataract, investigating aqueous humor, anterior capsule and lens human samples. Outstanding proteomic pr...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045554 | Pride
Keywords cataract Aqueous humor Aging Vitrectomy Diabetes Crystallin Cytoskeleton Proteomics 
GenomicsUpregulation of N6-methyladenosine Transcript Landscape in Diabetic Cataract
Upregulation of N6-methyladenosine Transcript Landscape in Diabetic Cataract
PRJNA810045 | ENA
OtherUpregulation of N6-methyladenosine Transcript Landscape in Diabetic Cataract
Epitranscriptomic profiling of human LECs of DC patients comparing normal control LECs. Goal was todetermine the potential functions and mechanism of N6-methyladenosine (m6A) abnormality of RNAs in human lens epithelium cell (HLEC) lesions in diabetic cataract (DC).
ORGANISM(S): Homo sapiens 
2025-02-22 | GSE197371 | GEO
UnknownEvaluation of nepafenac in prevention of macular edema following cataract surgery in patients with diabetic retinopathy.
Not available
S-EPMC3422154 | biostudies-literature
GenomicsDelay of Diabetic Cataract Progression by a Chemical Chaperone Trimethylamine N-Oxide through Alleviating Unfolded-Protein-Induced ER Stress
Delay of Diabetic Cataract Progression by a Chemical Chaperone Trimethylamine N-Oxide through Alleviating Unfolded-Protein-Induced ER Stress
PRJNA1495882 | ENA
TranscriptomicsDelay of Diabetic Cataract Progression by a Chemical Chaperone Trimethylamine N-Oxide through Alleviating Unfolded-Protein-Induced ER Stress
Diabetic cataract (DC), characterized by lens cloudiness, is a leading cause of visual impairment in diabetic individulas. This study aims to investigate the protective effects of trimethylamine N-oxide (TMAO), a natural occurring chaperone, on delaying diabetic cataract (DC) progression. In vivo an...
ORGANISM(S): Homo sapiens 
2026-09-24 | GSE338786 | GEO
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