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MetabolomicsMeasurements of fecal bile acids abundance in DSS induced UC mice model

Background and aims: Elevation of conjugated primary bile acid—GCA in fecal samples was reported in IBD patients compared to healthy controls (nearly 10-fold), as well as in active ulcerative colitis (UC) patients relative to those in remission stages. Therefore we wanted to investigate the poten...

2026-05-03 | MTBLS14031 | MetaboLights
MetabolomicsEnterobacter ludwigii protects DSS-induced colitis through choline-mediated immune tolerance
Commensal intestinal bacteria play key roles in regulating cells mediating immune tolerance; however, bacterial strains and related metabolites directly involved in this regulation are largely unknown. Here, using a mouse model of dextran sulfate sodium (DSS)-induced colitis combined with different ...
2024-08-05 | MTBLS5585 | MetaboLights
MetabolomicsMeasurements of fecal glycocholic acid abundance in DSS induced UC mice model treated with 200 mg per kg glycocholic acid

Background: Unlike the reported CA, the abundance of fecal GCA did not significantly increase after DSS treatment in C57BL/6J mice. Hence, exogenous supplementation of GCA were given to DSS-induced colitis mice via oral gavage. We want to know whether GCA treatment at 200 mg/kg yielded fecal GCA ...

2026-05-03 | MTBLS14032 | MetaboLights
MetabolomicsMetabolomic profiling of zebrafish DSS-induced colitis intervened by Akkermansia muciniphila-derived extracellular vesicles (AmEVs)
This study performs untargeted metabolomics analysis on intestinal tissues of DSS-induced colitis zebrafish models to uncover the metabolic regulatory mechanisms of AmEVs. We compared intestinal metabolite profiles between two experimental groups: DSS-induced colitis model group and AmEV interventio...
2026-07-22 | MTBLS14855 | MetaboLights
MetabolomicsFecal short-chain fatty acids in DSS-induced colitis mice treated with a D-lactate-free probiotic
Targeted GC-MS quantification of short- and branched-chain fatty acids in feces of C57BL/6J (B6J-UniBe) mice with acute dextran sulfate sodium (DSS)-induced colitis. Mice received the D-lactate-free probiotic consortium Pro4-50 by daily oral gavage either from the start of the experiment (Pre, n=10)...
2026-10-08 | MTBLS15952 | MetaboLights
MetabolomicsBupleurum chinense DC polysaccharides ameliorate DSS-induced ulcerative colitis by regulating gut microbiota and tryptophan metabolism via NF-κB pathway

Background: Bupleurum chinense DC polysaccharide (BCP) demonstrates a significant role in ameliorating gastric ulceration and enhancing intestinal barrier function, and have broad medicinal value. Nevertheless, the therapeutic effects and mechanisms in ulcerative colitis (UC) remain to be elucida...

2026-02-01 | MTBLS13814 | MetaboLights
MetabolomicsReactive Oxygen Species Deficiency Due to Ncf1-Mutation Leads to Development of Adenocarcinoma and Metabolomic and Lipidomic Remodeling in a New Mouse Model of Dextran Sulfate Sodium-Induced Colitis
Inflammatory bowel disease is characterized by chronic relapsing idiopathic inflammation of the gastrointestinal tract and persistent inflammation. Studies focusing on the immune-regulatory function of reactive oxygen species (ROS) are still largely missing. In this study, we analyzed an ROS-deficie...
2019-05-22 | MTBLS593 | MetaboLights
TranscriptomicsAnatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis.
Objective: In this study, we aimed to evaluate the anti-inflammatory properties of nicotine and anatabine in a dextran sulfate sodium (DSS) mouse model of ulcerative colitis (UC). Methods: C57BL/6 male mice (10 groups with 8 animals each) were orally administered nicotine at a concentration of 5 or ...
ORGANISM(S): Mus musculus 
2020-11-03 | E-MTAB-8543 | biostudies-arrayexpress
ProteomicsInvestigating the mechanism of action of IVIG in DSS-induced colitis mice through proteomics.
In this study, a mouse model of dextran sulfate sodium (DSS)-induced colitis was employed to investigate the role and mechanism of IVIG by proteomics.
ORGANISM(S): Mus musculus (Mouse) 
2026-07-28 | PXD068491 | Pride
Ivig dss-induced colitis mice proteomics. 
MetabolomicsUntargeted LC–MS serum metabolomics in a colitis mouse model treated with the microbiota-regulating nanomedicine MRA@RP

This study applies untargeted liquid chromatography–mass spectrometry (LC–MS)–based serum metabolomics to characterize metabolic alterations in a dextran sulfate sodium–induced colitis mouse model and to evaluate the therapeutic effects of the microbiota-regulating nanomedicine MRA_RP. Serum samp...

2025-11-22 | MTBLS13367 | MetaboLights
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