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ProteomicsIdentification and functional annotation of the Src-regulated kinome, part 2
Despite significant progress, our understanding of how specific oncogenes transform cells is still limited and likely underestimates the complexity of downstream signalling events. Herein, we describe a novel, integrated approach that addresses this knowledge gap. This utilizes mass spectrometry-bas...
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD011146 | Pride
Lc-msms Kinome Phosphoproteome 
ProteomicsActive kinome in human skeletal muscle insulin resistance
Obesity-related insulin resistance (OIR) is one of the main contributors to type 2 diabetes and other metabolic diseases. Protein kinases are implicated in key signaling steps including insulin signaling and glucose metabolism. Molecular mechanisms underlying OIR involving global active kinases rema...
ORGANISM(S): Homo sapiens (Human) 
2020-01-23 | PXD011909 | Pride
Quantitative proteomics Protein kinase Human skeletal muscle Insulin resistance Active kinome 
ProteomicsCharacterisation of the Active Kinome of Leishmania
Background: Leishmania parasites cause neglected tropical diseases such as cutaneous and visceral leishmaniasis, which have limited treatment options and rising drug resistance. Protein kinases are pivotal in Leishmania biology and attractive drug targets, but their functional status in the parasite...
ORGANISM(S): Leishmania mexicana 
2025-12-18 | PXD066933 | Pride
Parasite Drug target Leishmania Chemoproteomics Neglected tropical disease Activity-based protein profiling Protein kinase Kinome 
ProteomicsIdentification of MRCKA as an integral component of ovarian cancer signaling and a therapeutic target
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSOC...
ORGANISM(S): Homo sapiens (Human) 
2020-02-19 | PXD015849 | Pride
Human Mrcka High grade serous ovarian carcinoma Cdc42bpa 
UnknownComprehensive kinome NGS targeted expression profiling by KING-REX.
Not available
S-EPMC6480677 | biostudies-literature
UnknownActivity-based chemoproteomic profiling reveals the active kinome of <i>Leishmania</i>.
Not available
S-EPMC12816314 | biostudies-literature
UnknownKinome Profiling of Regulatory T Cells: A Closer Look into a Complex Intracellular Network.
Not available
S-EPMC4755507 | biostudies-literature
UnknownImpact of intrinsically disordered regions and functional disorder hotspots in the human kinome.
Not available
S-EPMC12696717 | biostudies-literature
ProteomicsBroad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma
Lenvatinib is the FDA-approved targeted drug for advanced hepatocellular carcinoma (HCC), but the efficacy is modest due to drug resistance. Tumor kinome re-wiring governs drug resistance in resistant cancer cells, which is an obstacle for efficient cancer therapy. Therefore, identification the kina...
ORGANISM(S): Homo sapiens (Human) 
2023-09-29 | PXD038152 | Pride
Beta-catenin Cancer stemness Hcc Cdk6 Lenvatinib 
UnknownFunctional kinome profiling reveals brain protein kinase signaling pathways and gene networks altered by acute voluntary exercise in rats.
Not available
S-EPMC11999169 | biostudies-literature
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