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ProteomicsThe small heat shock protein Alpha-Crystallin B shows neuroprotective properties in a glaucoma animal model
Aim of this study was the evaluation of Alpha-crystallin B and its potential neuroprotective properties in an experimentalanimal model of glaucoma with subsequent analysis of possible altered downstream markers in a complex mass spectrometric approach.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2017-11-28 | MSV000081755 | MassIVE
ProteomicsRetinal proteomic profiling in the course of experimental glaucoma
Intraocular pressure was elevated through episkleral vein occlusion by thermic cauterization of SD rats. Animals were further sacrificed after different periods of elevated IOP and the retinal proteins were investigated for alterations regarding the relative protein level in this experimental model ...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2017-11-28 | MSV000081757 | MassIVE
ProteomicsA monoclonal anti-HMGB1 antibody attenuates neurodegeneration in an experimental animal model of glaucoma
Neuroinflammation is a crucial process for the loss of retinal ganglion cells (RGC), a major characteristic of glaucoma. High expression of high mobility group box protein 1 (HMGB1) plays a detrimental role in inflammatory processes and is elevated in the retinas of glaucoma patients. Therefore, thi...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-20 | PXD031987 | Pride
Glaucoma Discovery proteomics Neuroprotection Microarray Antibodies Neurodegeneration Animal model 
ProteomicsThe small heat shock protein Alpha-Crystallin B shows neuroprotective properties in a glaucoma animal model
Aim of this study was the evaluation of Alpha-crystallin B and its potential neuroprotective properties in an experimentalanimal model of glaucoma with subsequent analysis of possible altered downstream markers in a complex mass spectrometric approach.
ORGANISM(S): Rattus norvegicus (Rat) 
2017-11-21 | PXD007751 | Pride
Experimental glaucoma  alpha-crystallin b  neuroprotection  proteomics 
ProteomicsProteomic analysis of retinal tissue in an S100B autoimmune glaucoma model
Glaucoma is not only the second leading cause of blindness worldwide, but patient numbers will also increase significantly in the coming years due to aging societies. Glaucoma is a progressive optic neuropathy with changes at the optic nerve head, gradual retinal ganglion cell (RGC) death, and visua...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-16 | PXD023995 | Pride
Autoimmune glaucoma Proteomics Ls-ms/ms Normal tension S100b 
TranscriptomicsTranscription profiling of mouse model of glaucoma retinal RNA from DBA/2J mice at 3 months before disease onset, and at 8 months, after IOP elevation
Purpose: The DBA/2J mouse is a model for secondary angle-closure glaucoma due to iris atrophy and pigment dispersion, which ultimately leads to increased intraocular pressure (IOP). We sought to correlate changes in retinal gene expression with glaucoma-like pathology by performing microarray analys...
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-3554 | biostudies-arrayexpress
ProteomicsRetinal proteomic profiling in the course of experimental glaucoma
Intraocular pressure was elevated through episkleral vein occlusion by thermic cauterization of SD rats. Animals were further sacrificed after different periods of elevated IOP and the retinal proteins were investigated for alterations regarding the relative protein level in this experimental model ...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-04-11 | PXD005258 | Pride
Proteomics Glaucoma Retina Ocular hypertension Crystallins 
ProteomicsProteomics-Based Identification of Retinal Protein Networks Impacted by Elevated Intraocular Pressure in the Hypertonic Saline Injection Model of Experimental Glaucoma
Elevated intraocular pressure is considered a major cause of glaucomatous retinal neurodegeneration. To facilitate a better understanding of the underlying molecular processes and mechanisms, we report a study focusing on alterations of the retina proteome by induced ocular hypertension in a rat mod...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-24 | PXD042729 | Pride
Retina proteomics  glaucoma  ocular hypertension  brown norway rat model  bioinformatics  pathway analysis  protein networks 
UnknownAnimal Model Contributions to Primary Congenital Glaucoma.
Not available
S-EPMC9162845 | biostudies-literature
UnknownNovel Use of PLGA Microspheres to Create an Animal Model of Glaucoma with Progressive Neuroretinal Degeneration.
Not available
S-EPMC7915113 | biostudies-literature
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