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TranscriptomicsComparison of the transcriptomes of hmgb1 vs Col-0
Testing the consequences of the absence of the chromatin-associated HMGB1 protein on the transcriptome in Arabidopsis. Keywords: Comparison of mutant and wildtype samples. Four replicate RNA extractions were performed of each genotype using independent pools of plants. hmgb1#1 (Cy5) vs. Col-0#1 (Cy3...
ORGANISM(S): Arabidopsis thaliana 
2008-11-23 | E-GEOD-10638 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis (nCounter Human Immunology v2 Panel) of A549 cells with HMGB1 knockdown and infected with WT or attenuated mutant Dengue virus 2 strains
HMGB1 were silence in A549 cells using siRNA targeting.These A549 cells were then infected with WT Dengue virus 2 and its attenuated mutants (generated using infectious clone construction with site-directed mutagenesis) to better understand the gene expression changes induced by these different atte...
ORGANISM(S): Homo sapiens 
2026-05-14 | E-MTAB-16204 | biostudies-arrayexpress
ProteomicsTumor cells express and maintain HMGB1 in the reduced isoform to enhance CXCR4-mediated migration
During inflammation and tissue regeneration, the alarmin High Mobility Group Box 1 (HMGB1), in its reduced isoform, enhances the activity of the chemokine CXCL12, forming a heterocomplex that acts via the chemokine receptor CXCR4. Despite the established roles of both HMGB1 and CXCL12 in tumor progr...
ORGANISM(S): Homo sapiens (Human) 
2024-05-02 | PXD048091 | Pride
Breast cancer Thioredoxin Heterocomplex Cxcl12 Hmgb1 Prostate cancer 
ProteomicsHMGB1 interactome in prostate and ovarian cancer cells
This study reports the interactome of HMGB1 in prostate and ovarian cancer cells, which includes a variety of proteins involved in diverse cellular processes. Subcellular fractionation is used to map the distribution of interacting proteins. In the nucleus, HMGB1 interacts directly with NuRD complex...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026258 | Pride
Septin Thoc complex Prostate cancer Ovarian cancer Ribosome biogenesis Hmgb1 Skov-1 Nurd complex Rab11 Pc3 
ProteomicsHMGB1 interactome in prostate and ovarian cancer cells treated with cisplatin
Cisplatin is used in chemotherapy of prostate, ovary and other cancer types but unfortunately the efficiency of cisplatin treatment is frequently hampered by acquired resistance. The cytotoxic effect of cisplatin has been attributed to its binding to DNA. HMGB1 is able to bind to cisplatin-DNA adduc...
ORGANISM(S): Homo sapiens (Human) 
2021-11-01 | PXD026309 | Pride
Pc-3 Prostate cancer Ovarian cancer Skov-3 Cisplatin Hmgb1 Interactome 
GenomicsChromatin IP sequencing of the nuclear factor HMGB1 in livers from mice after a metabolic stress either induced by a 12-week high fat diet consumption or a fasting (6hours)-refeeding (8hours) challenge.
To unveil HMGB1 DNA occupancy in livers of mice after a metabolic stress either induced by a 12-week high fat diet consumption or a fasting (6hours)-refeeding (8hours) challenge. Challenges known to generate a robust activation of hepatic lipogenesis and liver steatosis.
ORGANISM(S): Mus musculus 
2022-03-31 | E-MTAB-11543 | biostudies-arrayexpress
ProteomicsCharacterisation of HMGB1 interactome in PNT2 prostate cells
HMGB1 and HMGB2 are members of the High Mobility Group (HMG) protein superfamily that contain a DNA binding domain (HMG-Box), and their overexpression has been related to main cancer hallmarks, tumor progression, metastasis formation and bad prognosis. We have used yeast two hybrid and affinity puri...
ORGANISM(S): Homo sapiens (Human) 
2018-05-07 | PXD007867 | Pride
Lc-msms Prostate Cancer Affinity purification Ovary 
TranscriptomicsThe effects of Hmgb1 depletion on gene expression in murine cells
High Mobility Group Box 1 (HMGB1) is a highly abundant and evolutionarily conserved non-histone chromatin component with the ability to bind and bend DNA. The protein is involved in fundamental nuclear processes including nucleosome sliding, transcription, replication, V(D)J recombination and DNA tr...
ORGANISM(S): Mus musculus 
2013-10-01 | E-GEOD-18463 | biostudies-arrayexpress
TranscriptomicsThe effects of Hmgb1 depletion on gene expression in human cells
High Mobility Group Box 1 (HMGB1) is a highly abundant and evolutionarily conserved non-histone chromatin component with the ability to bind and bend DNA. The protein is involved in fundamental nuclear processes including nucleosome sliding, transcription, replication, V(D)J recombination and DNA tr...
ORGANISM(S): Homo sapiens 
2011-06-28 | E-GEOD-18721 | biostudies-arrayexpress
ProteomicsHMGB1 ubiquitination related sites
HMGB1 ubiquitination related sites detected by IP-Mass
ORGANISM(S): Homo Sapiens 
2023-07-19 | PXD043938 |
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