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Background: Obesity is characterized as a disease that directly affects the whole-body metabolism and is associated with excess fat mass and several related comorbidities. Dynamics of the adipocyte hypertrophy and hyperplasia play an important role in health and disease, especially in obesity. Human...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026299 | Pride
Ribosome profiling followed of next-generation sequencing (Ribo-seq) of undifferentiated human adipose-derived stem cells (hASC).
DNA methylation of neural differentiation from human adipose derived stem cells
Exosomes derived from human adipose tissue mesenchymal stem cells (hASCs) have demonstrated anti-inflammatory and rejuvenating properties, making them promising agents for neurochemical intervention. However, their transcriptomic impact on neuronal cells remains largely unexplored. To address this r...
ORGANISM(S): Mus musculus 
Differentiation of mesenchymal stem cells into adipocytes was studied. Control (undifferentiated) stem cells were compared to induced (3 days of induction) cells. In addition, two RNA fractions are studied: RNA associated to polysomes and total RNA.
ORGANISM(S): Homo sapiens 
Traumatic brain injury (TBI) is a major cause of long-term neurological impairment, with aging amplifying vulnerability and worsening recovery. Older individuals face greater cognitive and motor deficits post-TBI and respond less effectively to treatments, as both aging and TBI independently elevate...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-11 | PXD067584 | Pride
Transcriptomic Modulation by Exosomes Derived from Human Adipose Stem Cells in Neuronal Cells
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