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MetabolomicsGSDME-controlled pyroptosis promotes muscle repair by coordinating tissue resident macrophages and fibro-adipogenic progenitors
GSDME (Gasdermin E) is a critical protein known for its role in pyroptosis, a form of programmed cell death associated with inflammation. We demonstrated that GSDME as a crucial mediator in muscle repair, particularly in the context of muscle damage induced by cardiotoxin (CTX). Specifically, we fou...
2026-01-05 | MTBLS10509 | MetaboLights
MetabolomicsLipidomic profiling of Scd1- and Scd2-deficient C2C12 cells during brown adipogenic differentiation with oleic acid supplementation
This study investigated the lipidomic remodeling of Scd1- and Scd2-deficient C2C12 cells during brown adipogenic differentiation. Scd1 or Scd2 knockout cells and corresponding control cells were induced to undergo brown adipocyte-like differentiation for 96 h. To evaluate whether exogenous monounsat...
2026-06-23 | MTBLS14692 | MetaboLights
ProteomicsHuman BMSCs protein analysis that interact with TRAF4 during adipogenic differentiation
To explore the mechanism underlying the negative regulation of adipogenesis by TRAF4, we performed the LC-MS/MS experiments to identify the proteins that interact with TRAF4 during adipogenic differentiation.
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD017524 | Pride
Human Mscs Traf4 Adipogenic 
TranscriptomicsTranscription factor cooperativity in early adipogenic hotspots and super-enhancers
Here we have used a combination of advanced proteomics and genomics approaches to investigate the extent and mechanisms of transcription factor cross-talk at genomic hotspots. We identify ~12,000 transcription factor hotspots in the early phase of adipogenesis, and we find evidence of both simultane...
ORGANISM(S): Mus musculus 
2014-04-17 | E-GEOD-56872 | biostudies-arrayexpress
TranscriptomicsDiverse effects of cyclic AMP variants on osteogenic and adipogenic differentiation of human mesenchymal stromal cells
Osteogenic differentiation of human mesenchymal stromal cells (hMSCs) may potentially be used in cell-based bone tissue-engineering applications to enhance the bone-forming potential of these cells. Osteogenic differentiation and adipogenic differentiation are thought to be mutually exclusive, and a...
ORGANISM(S): Homo sapiens 
2018-08-05 | E-MTAB-7038 | biostudies-arrayexpress
ProteomicsColchicine Suppresses Adipogenic Differentiation of Mesen-chymal Stem Cells: Implications for Bone Adiposity Control
Background: Gout is an inflammatory arthritis associated with increased bone anabolism and a higher risk of ectopic bone formation. Colchicine, used to prevent and treat acute gouty flares, inhibits microtubule polymerization and has been described to promote osteoblastogenesis. In bone disorders su...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-02 | PXD072951 | Pride
Adipogenesis  osteoblastogenesis  cytoskeleton  microtubule destabilization  bone marrow adipocytes 
GenomicsGenome-wide maps of TCF7L1 binding during early adipogenesis
Here we show through genome-wide binding studies that transcription factor 7-like 1 (TCF7L1) represses structure-related genes during adipogenesis. Intriguingly, TCF7L1 is induced in a cell contact-dependent manner by confluency in preadipocytes and is required for adipocyte differentiation by repre...
ORGANISM(S): Mus musculus 
2011-09-02 | E-GEOD-31867 | biostudies-arrayexpress
GenomicsPropagation of Adipogenic Signals through an Epigenomic Transition State
The transcriptional mechanisms by which temporary exposure to developmental signals instigates adipocyte differentiation are unknown. During early adipogenesis, we find transient enrichment of the glucocorticoid receptor (GR), CCAAT/enhancer binding protein b (CEBPb), p300, mediator subunit 1, and h...
ORGANISM(S): Mus musculus 
2010-05-20 | E-GEOD-21898 | biostudies-arrayexpress
ProteomicsFibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis
Fibro adipogenic progenitors (FAPs) promote satellite cell differentiation in adult skeletal muscle regeneration. However, in pathological conditions, FAPs are responsible for fibrosis and fatty infiltrations. Here we show that the NOTCH pathway negatively modulates FAP differentiation both in vitro...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-24 | PXD014195 | Pride
Adipogenesis Notch Inflammation Muscular dystrophy Myopathies Skeletal muscle regeneration Mass cytometry Fibro adipogenic progenitors Proteome 
TranscriptomicsSmall RNA-sequencing of Fibro-Adipogenic Progenitors (FAPs) upon Histone Deacetylase inhibition in young mdx mice
Fibro-adipogenic progenitors (FAPs) are emerging cellular components of the skeletal muscle regenerative environment. The alternative functional phenotype of FAPs - either supportive of muscle regeneration or promoting fibro-adipogenic degeneration - is a key determinant in the pathogenesis of muscu...
ORGANISM(S): Mus musculus 
2014-04-23 | E-GEOD-51933 | biostudies-arrayexpress
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