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TranscriptomicsGene expression profile of myeloma cells treated with IGF-1
Objective of this study was to find changes in gene expression of mouse multiple myeloma cells upon treatment with IGF-1 Murine multiple myeloma cells were incubated in serum free medium for 12 hours in the absence (3 replicates) or presence (3 replicates) of 100 ng/ml IGF-1
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-17140 | biostudies-arrayexpress
TranscriptomicsNeurotrophic factors and their receptors are altered by the mere partial IGF-1 deficiency
Neurotrophic factors (NTFs) are a relevant group of secreted proteins that modulate growth, differentiation, repair, and survival of neurons; playing a role in the maintenance of the synaptic unions, dendrites and axons; also, being crucial for peripheral nervous system development and regulating pl...
ORGANISM(S): Mus musculus 
2018-12-29 | E-MTAB-7508 | biostudies-arrayexpress
ProteomicsIdentification of phosphorylation sites in the IGF-1 Receptor
Although Insulin-like Growth Factor (IGF-1) signaling promotes tumor growth and cancer progression, IGF-1 Receptor-targeted therapies have shown poor clinical efficacy. The mechanistic basis for this is unclear as is our understanding of what distinguishes IGF-1R signaling from the closely related I...
ORGANISM(S): Homo sapiens (Human) 
2020-05-15 | PXD017644 | Pride
Tyr1131 Tyr1135 Tyr1136 Igf-1 Tyr125051 Igf-1 receptor 
GenomicsHistone Demethylase UTX-1 Regulates the Caenorhabditis elegans Lifespan by Targeting the Insulin/IGF-1 Signaling Pathway
Epigenetic modifications are thought to be important for gene expression changes during development and aging. However, besides the Sir2 histone deacetylase in somatic tissues and H3K4 trimethylation in germlines, there is scant evidence implicating epigenetic regulations in aging. The insulin/IGF-1...
ORGANISM(S): Caenorhabditis elegans 
2011-11-22 | E-GEOD-29896 | biostudies-arrayexpress
GenomicsGenome-wide analysis of insulin-like growth factor 1 receptor (IGF1R) binding sites in DFB cells
The insulin-like growth factor 1 receptor (IGF-1R) plays crucial roles in developmental and cancer biology. Most of its biological effects have been ascribed to its tyrosine kinase activity. We report that IGF-1 promotes the modification of IGF-1R by small ubiquitin-like modifier protein-1 (SUMO-1) ...
ORGANISM(S): Homo sapiens 
2010-08-25 | E-GEOD-23792 | biostudies-arrayexpress
ProteomicsReduced IGF-1 signaling fails to limit Alzheimer’s disease progression in a novel rat model of IGF-1R haploinsufficiency
The growth hormone/insulin-like growth factor-1 (GH/IGF-1) signaling pathway has been strongly implicated in the aging process. Lifespan is profoundly increased in both male and female dwarf mice, while low IGF-1 signaling per se leads to more modest improvements in female lifespan. However, as oppo...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-27 | PXD068498 | Pride
Insulin resistance Alzheimer’s disease Igf-1r Rat Igf-1 
TranscriptomicsCirculating insulin-like growth factor (IGF)-1 Regulates Hippocampal IGF-1 Levels and Brain Gene Expression During Adolescence
This study, using a growth hormone (GH)-deficient dwarf animal model and peripheral GH replacement, investigated the effects of circulating IGF-1 during adolescence on IGF-1 levels in the brain. Our results demonstrated that hippocampal IGF-1 protein concentrations during adolescence are highly regu...
ORGANISM(S): Rattus norvegicus 
2011-07-20 | E-GEOD-29512 | biostudies-arrayexpress
TranscriptomicsMurine small intestinal crypt cells: IGF-1 stimulated vs. control
microRNA profiling of mouse small intestinal crypt cells comparing control untreated with cells treated with insulin growth factor-1 (IGF-1). IGF-1 stimulated cell proliferation, as observed in Brdu incoporation assay. Two condition experiment. Control vs IGF-1 treatment. Biological replicates: 3 co...
ORGANISM(S): Mus musculus 
2010-11-01 | E-GEOD-20133 | biostudies-arrayexpress
TranscriptomicsDomain-Dependent Effects of Insulin and IGF-1 Receptors on Preadipocyte Gene Expression
Despite a high degree of homology, insulin and IGF-1 receptors (IR/IGF1R) mediate distinct cellular and physiological functions. Here, using chimeric and site-mutated receptors, we demonstrate how domain differences between IR and IGF1R contribute the distinct functions of these receptors. Receptors...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81921 | biostudies-arrayexpress
GenomicsIGF-1-mediated microRNA profile in glioblastoma
IGF-1-mediated microRNA profile in glioblastoma
PRJNA589263 | ENA
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