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ProteomicsAkt2 partners L6 myoblasts - Novel Endogenous, Insulin-Stimulated Akt2 Protein Interaction Partners in L6 Myoblasts
Insulin resistance and Type 2 diabetes are marked by an aberrant response in the insulin signaling network. The phosphoinositide-dependent serine/threonine kinase, Akt2, plays a key role in insulin signaling and glucose uptake, most notably within skeletal muscle. Protein-protein interaction regul...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-30 | PXD002557 | Pride
Akt2 Hplc-esi-ms/ms Rock2 
ProteomicsRegulation of the HTRA2 protease activity by PDZ domain-binding peptide ligands and the influence on HTRA2-specific protein interaction networks in retinal tissues
For the identification of HTRA2-specific protein interaction partners in retinal tissues of the house swine (Sus scrofa), we performed co-immunoprecipitation experiments with recombinant 6His-tag HTRA2 followed by quantitative LC-MS-based proteomics (see Fig. 2A and File S1). In brief, 2 µg recombin...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2021-10-11 | PXD024442 | Pride
Htra2  neuroprotection  retina  interaction partners  co-immunoprecipitation  mass spectrometry 
ProteomicsIdentification of Candidate Interaction Partners of Human Calpain-5 in Neuroblastoma Cells with SWATH-MS Analysis
Few interaction partners of human calpain-5/CAPN5 have been identified or proposed. This project was designed to identify candidate interaction partners of CAPN5 in SH-SY5Y neuroblastoma cells. We utilized sequential window acquisition of all theoretical mass spectra (SWATH‐MS) for proteomic analysi...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD068008 | Pride
Human Capn5 Neuroblastoma Proteomics Calpain-5 Interaction partner Mass spectrometry Immunoprecipitation 
ProteomicsIdentification of the B7-H3 Interaction Partners Using a Proximity Labeling Strategy
B7-H3 has emerged as a promising target for cancer therapy due to its high expression in various types of cancer cells. It not only regulates the activity of immune cells but also modulates the signal transduction and metabolism of cancer cells. However, the specific interaction partners of B7-H3 st...
ORGANISM(S): Homo Sapiens 
2024-12-23 | PXD059197 |
ProteomicsQuantitative GTPase affinity purification identifies Rho family protein interaction partners
Although Rho GTPases are essential molecular switches involved in many cellular processes, an unbiased experimental comparison of their interaction partners was not yet performed. Here, we develop quantitative GTPase affinity purification (qGAP) to systematically identify interaction partners of six...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2016-12-23 | PXD004190 | Pride
Interaction proteomics Rho gtpase 
ProteomicsInteraction partners of arginyl-tRNA protein transferase in the moss Physcomitrella patens
Protein arginylation is a post-translational modification at the N-terminus of proteins and is crucial for viability and physiology in higher eukaryotes. The lack of arginylation causes severe developmental defects in plants and embryo lethality in Drosophila and in mice. Although several studies in...
ORGANISM(S): Physcomitrella patens subsp. patens (Moss) 
2016-04-19 | PXD003228 | Pride
Moss Protein interaction Co-ip Physcomitrella patens Lc-ms/ms 
GenomicsFOXL2 interaction with different binding partners regulates the dynamics of ovarian development
FOXL2 interaction with different binding partners regulates the dynamics of ovarian development
PRJNA992534 | ENA
ProteomicsThe identification of bacterial protein interaction partners pointed out to new intracellular functions of Francisella tularensis glyceraldehyde-3-phosphate dehydrogenase
Glyceraldehyde-3-phopshate dehydrogenase (GAPDH) is well-known for its involvement in numerous non-metabolic processes inside the mammalian cells. Alternative functions of prokaryotic GAPDH are mainly deduced from its extracellular localization and the ability to bind to selected host proteins. Data...
ORGANISM(S): Francisella tularensis subsp. holarctica FSC200 Bacteria 
2020-08-31 | PXD019739 | Pride
Interaction partners Francisella tularensis 
ProteomicsA mass spectrometry-based approach for the identification of Kpnβ1 binding partners in cancer cells
Karyopherin beta 1 (Kpnβ1) is the principal nuclear importer of cargo proteins and plays a role in many cellular processes. Its expression is upregulated in cancer and essential for cancer cell viability, thus the identification of its binding partners might help in the discovery of anti-cancer ther...
ORGANISM(S): Homo sapiens (Human) 
2022-11-03 | PXD034805 | Pride
Cancer Kpnb1 
GenomicsIdentification of Elg1 interaction partners and effects on post-replication chromatin re-formation
Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation
PRJEB27808 | ENA
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