Calpain-5 - OmicsDI

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Metabolite Name

Thr-Pro-Arg (1)
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L-valine, n-[[1-(5-fluoropentyl)-1h-indol-3-yl]carbonyl]-, methyl ester (1)
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5-methoxy-4-methyl-3-phenylcoumarin (1)
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3-quinolinecarboxamide, 1,4-dihydro-8-methoxy-4-oxo-1-pentyl-n-tricyclo[3.3.1.13,7]dec-1-yl- (1)
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[[4-[5r-chloro-2z-[3r-cyclohexyl-3s-hydroxy-1r-propenyl]-3s-hydroxycyclopentyl]-2r-butenyl]oxy]-acetic acid, isopropyl ester (1)
(s)-n-(1-amino-1-oxo-3-phenylpropan-2-yl)-1-pentyl-1h-indole-3-carboxamide (1)
(3as,5r,5as,8as,9ar)-5,8a-dimethyl-1-methylidene-3a,4,5,5a,6,7,9,9a-octahydroazuleno[6,7-b]furan-2,8-dione (1)
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Solasodine base + 2h, 1o, o-hex-hex-hex (1)
Cyanidin 3-o-[2''-o-(xylosyl)-6''-o-(p-o-(glucosyl)-p-coumaroyl) glucoside] 5-o-glucoside (1)
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(z)-2-octylpent-2-enedioic acid (1)
Cocamidoprpylbetaine (1)
.alpha.-galactosyl-n-stearoylsphingosine (1)
Ser-Ser-Arg (1)

First Public Date

2019 (2)
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Study type

Transcription profiling by array (17)
ChIP-seq (3)
Methylation profiling by high throughput sequencing (3)
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2001 (1)

Lab affiliation

Director, MaineHealth Institute for Research, Proteomics and Lipidomics Laboratory (1)
Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and BIOSS Centre for Biological Signalling Studies University of Freiburg, 79104 Freiburg, Germany (1)
Director, Proteomics and Lipidomics Core Facility, Mainehealth (1)
Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and BIOSS Centre for Biological Signalling Studies University of Freiburg, 79104 Freiburg, Germany (1)
Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Alberta T2N 1N4 Canada Snyder Insitute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Alberta T2N 1N4 Canada (1)
Division of Cardiology, Department of Medicine; Columbia University, Vagelos College of Physicians and Surgeons, 622 West 168th Street, New York, NY 10032. Department of Pharmacology and Molecular Signaling, Columbia University, Vagelos College of Physicians and Surgeons (1)
Chemical Proteomics, Division of Chemistry I, Department of Medical Biochemistry and Biophysiscs (MBB), Karolinska Institutet, Stockholm, Sweden (1)
Calpain Project Department of Advanced Science for Biomolecules Igakuken (Tokyo Metropolitan Institute of Medical Science) 2-1-6 Kamikitazawa, Setagaya-ku Tokyo 156-8506, Japan (1)

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Identification of Candidate Interaction Partners of Human Calpain-5 in Neuroblastoma Cells with SWATH-MS Analysis

Few interaction partners of human calpain-5/CAPN5 have been identified or proposed. This project was designed to identify candidate interaction partners of CAPN5 in SH-SY5Y neuroblastoma cells. We utilized sequential window acquisition of all theoretical mass spectra (SWATH‐MS) for proteomic analysi...

ORGANISM(S): Homo sapiens (Human)

2026-02-02 | PXD068008 | Pride

The Identification of Proteolytic Substrates of Calpain-5 with N-terminomics

Calpain-5/CAPN5 is a calcium-activated, non-lysosomal cysteine (thiol) protease. The substrate spectrum repertoire of CAPN5 is not known. Calpains catalyze limited proteolysis of their substrates, generating novel neo protein N-termini that correspond to internal residues of their nascent substrate ...

ORGANISM(S): Homo sapiens (Human)

2025-07-21 | PXD064313 | Pride

Capn5 Protease Disease Tails N-terminomics Calpain-5

Small-angle X-ray scattering of calpain-5 reveals a highly open conformation among calpains.

Not available

S-EPMC5118095 | biostudies-literature

Calpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor degeneration.

Not available

S-EPMC3464205 | biostudies-literature

Olfactory marker protein is unlikely to be cleaved by calpain 5.

Not available

S-EPMC9618205 | biostudies-literature