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UnknownAn anti-CAPN5 intracellular antibody acts as an inhibitor of CAPN5-mediated neuronal degeneration.
Not available
S-EPMC5725022 | biostudies-literature
ProteomicsIdentification of Candidate Interaction Partners of Human Calpain-5 in Neuroblastoma Cells with SWATH-MS Analysis
Few interaction partners of human calpain-5/CAPN5 have been identified or proposed. This project was designed to identify candidate interaction partners of CAPN5 in SH-SY5Y neuroblastoma cells. We utilized sequential window acquisition of all theoretical mass spectra (SWATH‐MS) for proteomic analysi...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD068008 | Pride
Human Capn5 Neuroblastoma Proteomics Calpain-5 Interaction partner Mass spectrometry Immunoprecipitation 
UnknownCAPN5 genetic inactivation phenotype supports therapeutic inhibition trials.
Not available
S-EPMC7493429 | biostudies-literature
UnknownProteomic insight into the pathogenesis of CAPN5-vitreoretinopathy.
Not available
S-EPMC6527583 | biostudies-literature
UnknownCapn5 Expression in the Healthy and Regenerating Zebrafish Retina.
Not available
S-EPMC6054427 | biostudies-literature
ProteomicsThe Identification of Proteolytic Substrates of Calpain-5 with N-terminomics
Calpain-5/CAPN5 is a calcium-activated, non-lysosomal cysteine (thiol) protease. The substrate spectrum repertoire of CAPN5 is not known. Calpains catalyze limited proteolysis of their substrates, generating novel neo protein N-termini that correspond to internal residues of their nascent substrate ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD064313 | Pride
Capn5 Protease Disease Tails N-terminomics Calpain-5 
UnknownStructural modeling of a novel CAPN5 mutation that causes uveitis and neovascular retinal detachment.
Not available
S-EPMC4391918 | biostudies-literature
ProteomicsCapture of candidate calpain5 interacting proteins from lysates of the human neuroblastoma SH-SY5Y cell line with analysis of LC-MSMS data using SWATH
Calpain5 (CAPN5) is a nonclassical calpain in that it lacks a pentaEF hand domain. Although widely expressed dominantly inherited mutations of CAPN5 display phenotypes primarily localized to the eye. These experiments aimed to identify proteins from the neuroblastoma cell line SH-SY5Y that may inter...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD071887 | Pride
Sh-sy5y cell line Lc-msms Catalytic domain Swath Human Calpain5 
UnknownA novel de novo CAPN5 mutation in a patient with inflammatory vitreoretinopathy, hearing loss, and developmental delay.
Not available
S-EPMC5983175 | biostudies-literature
UnknownCAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model.
Not available
S-EPMC4512628 | biostudies-literature
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