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ProteomicsMag-Net: Rapid enrichment of membrane-bound particles enables high coverage quantitative analysis of the plasma proteome
Membrane-bound particles in plasma are composed of exosomes, microvesicles, and apoptotic bodies and represent ~1-2% of the total protein composition. Proteomic interrogation of this subset of plasma proteins augments the representation of tissue-specific proteins, representing a “liquid biopsy,” wh...
ORGANISM(S): Homo Sapiens 
PXD042947 | panorama
ProteomicsProteomic profiling of plasma-derived extracellular vesicles using Mag-Net for biomarker discovery in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer, with a five-year survival rate of less than 10%. In South Africa, PDAC was the seventh leading cause of cancer deaths among men and the sixth among women in 2020. Approximately 85% of patients are diagnosed at an advanced stage, ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-06 | PXD074950 | Pride
Pancreatic ductal adenocarcinoma (pdac)  biomarker  plasma  extracellular vesicles  mag-net  proteomics 
ProteomicsIsolation of EVs from Minimal Ascites Fluid Volume
Using Mag-Net beads to capture EVs from murine and human ascites fluid. Determine minimal volume of starting material needed for parallel proteomics and SERS analysis.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-09-07 | PXD068766 | Pride
Ovarian cancer Dia Extracellular vesicles Ascites Mag-net 
ProteomicsPlasma proteomics of ZDF and SD rat using Mag-Net and ENRICH-iST methods
One of the biggest challenges in Plasma Proteomics is to reduce the dynamic range of plasma proteins to capture the expression of low-abundant proteins. Mag-Net and ENRICH-iST methods were evaluated using 20 μL of type 2 diabetes (ZDF) and SD rat plasma by data-independent acquisition (DIA)-MS Mag-N...
ORGANISM(S): Cellular Organisms 
2026-05-20 | PXD067811 | JPOST Repository
ProteomicsProteomic characterization of checkpoint inhibitor-induced liver injury
Discovery proteomics of plasma samples from ChILI patients. EV enrichment was performed using Mag-Net protocol and samples were labelled with TMTpro.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-01-24 | MSV000096928 | MassIVE
ProteomicsAutomated MagNet Enrichment Unlocks Deep and Cost-Effective LC-MS Plasma Proteomics
Plasma is an ideal material for proteomics due to its diverse protein content reflecting physiological and pathological states, and its compatibility with minimally invasive sampling. Deep proteomic profiling of plasma is limited by high-abundant proteins that mask the detection of low-abundant prot...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-05-05 | MSV000097796 | MassIVE
ProteomicsHow blood matrices and sample preparation can influence blood marker discovery
While plasma and serum are increasingly being studied by using high throughput proteomics, it remains largely unexplored how different types of blood materials collected in the routine clinical diagnostics laboratories influence protein marker discovery. We compared the LC-MS/MS proteomic profiles o...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD066304 | Pride
Plasma Speed Mass spectrometry Enrich-ist Serum Lc−ms Ist R package mpwr Data-independent acquisition Perca Mag-net 
ProteomicsA Technical Evaluation of Plasma Proteomics Technologies
We report a technical evaluation of six notable plasma proteomics technologies from recent years. Unenriched plasma, perchloric acid depletion, PreOmics ENRICHplus, Mag-Net, Seer Proteograph XT, and Olink Explore HT. The methods were compared on proteomic depth, reproducibility, linearity, tolerance...
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2025-05-12 | PXD060573 | Pride
Plasma Lc-ms Proteomics 
ProteomicsA Technical Evaluation of Plasma Proteomics Technologies
We report a technical evaluation of six notable plasma proteomics technologies from recent years. Unenriched plasma, perchloric acid depletion, PreOmics ENRICHplus, Mag-Net, Seer Proteograph XT, and Olink Explore HT. The methods were compared on proteomic depth, reproducibility, linearity, tolerance...
ORGANISM(S): Homo sapiens (Human) 
2025-05-12 | PAD000002 | Pride
Affinity proteomics O-link 
ProteomicsDevelopment of highly multiplex targeted proteomics assays in biofluids using a nominal mass ion trap mass spectrometer
The development of targeted assays that monitor biomedically relevant proteins is an important step in bridging discovery experiments to large scale clinical studies. Targeted assays are currently unable to scale to hundreds or thousands of targets. We demonstrate the generation of large-scale assay...
ORGANISM(S): Homo Sapiens Gallus Gallus 
2026-01-12 | PXD065471 | panorama
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