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ProteomicsMolecular characterization of adhesives (glue lining pastes) used in restoration
The molecular characterization of samples from works of art can provide valuable insights into the composition of ancient restoration materials and their conservation state. Here, we present a novel experimental protocol for the molecular characterization of a specific adhesive used in historical pa...
ORGANISM(S): Bos taurus (Bovine) linum usitatissimum Oryctolagus cuniculus (Rabbit) Triticum aestivum (Wheat) Secale cereale Acipenser sturio 
2024-10-17 | PXD051480 | Pride
Restoration Extraction Gc-ms Proteomics Mass spectrometry Glue lining pastes Lc-ms/ms 
ProteomicsDesign principles for cyclin K molecular glue degraders
Molecular glue degraders are an effective therapeutic modality, but their design principles are not well understood. Recently, several unexpectedly diverse compounds were reported to deplete cyclin K by linking CDK12-cyclin K to the DDB1-CUL4-RBX1 E3 ligase. To investigate how chemically dissimilar ...
ORGANISM(S): Hordeum vulgare (Barley) 
2023-10-20 | PXD041836 | Pride
Ubiquitin Cdk12 Molecular glue Cr8 Cyclink Degrader 
ProteomicsChemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader
Discovery of a covalent molecular glue degrader that covalently interacts with UBE2D and engages in molecular glue interactions with NFKB1
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039924 | Pride
Molecular glue degraders 
ProteomicsAn engineered Cereblon optimized for high throughput screening and molecular glue discovery
The majority of clinical degraders utilize an immunomodulatory imide drug (IMiD)-based derivative, that directs their target to the E3 ligase receptor Cereblon (CRBN), however, identification of IMiD molecular glue substrates has remained underexplored. To tackle this, we design human CRBN construct...
ORGANISM(S): Homo sapiens (Human) 
2024-12-06 | PXD057393 | Pride
Cereblon Targeted protein degradation Molecular glue Imid Ubiquitin 
ProteomicsDiscovery and design of molecular glue enhancers of CDK12-DDB1 interactions for targeted degradation of cyclin K
The CDK12 inhibitor, SR-4835, promotes the proteasomal degradation of cyclin K, contingent on the presence of CDK12 and the CUL4-RBX1-DDB1 E3 ligase complex. The inhibitor displays molecular glue activity, which correlates with its enhanced ability to inhibit cell growth. This effect is achieved by...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053505 | Pride
Cdk12 Molecular glue degraders Cyclin k 
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047137 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047141 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047138 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
GenomicsTRI-611, a selective, brain-penetrant molecular glue degrader of ALK
TRI-611, a selective, brain-penetrant molecular glue degrader of ALK
PRJNA1459258 | ENA
GenomicsDiscovery of a molecular glue promoting CDK12-DDB1 interaction to trigger Cyclin K degradation [CRISPR]
Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger Cyclin K degradation [CRISPR]
PRJNA643767 | ENA
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