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TranscriptomicsExpression data of pachytene spermatocytes and round spermatids from young and aged Brown Norway rats
Male fertility and testis function changes with age and so it was sought to determine if these changes are accompanied by changes in gene expression. A full genome microarray was used to determine if distinct pathways of genes were altered in expression in germ cells (pachytene spermatocytes or roun...
ORGANISM(S): Rattus norvegicus 
2012-01-06 | E-GEOD-29963 | biostudies-arrayexpress
TranscriptomicsAlkbh1/Tzfp Repress a Non-Repeat piRNA Cluster in Pachytene Spermatocytes
Piwi proteins and Piwi-interacting small RNAs (piRNAs) have known functions in transposon silencing in the male germline of fetal and newborn mice. Both are also necessary for spermatogenesis in adult testes, however, their function here remains a mystery. Here, we use germ cell isolations and small...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-37150 | biostudies-arrayexpress
TranscriptomicsPachytene piRNAs target endogenous mRNAs for silencing during meiosis
During embryonic germ cell development in mice, transposon-enriched, piwi-interacting RNAs (piRNAs) guide MILI and MIWI2 to direct silencing of potentially active mobile element families. In contrast, we know much less about the function of the highly abundant and extremely diverse class of piRNAs, ...
ORGANISM(S): Mus musculus 
2015-05-22 | E-GEOD-64138 | biostudies-arrayexpress
UnknownSpermatocyte injection into meiotic oocytes rescues diplotene, but not pachytene, arrest in azoospermic mutant mice.
Not available
S-EPMC12628785 | biostudies-literature
TranscriptomicsTranscription profiling of mouse prospermatogonia, pachytene oogonia, and gonadal somatic cells from 15 day post-conceptus fetuses and pachytene spermatocytes from adults
RNA expression microarray analysis of prospermatogonia in 15 day post-conceptus (dpc) fetuses, a stage when they are undergoing rapid de novo DNA methylation. For comparison, we also analysed 15 dpc pachytene oogonia, 15 dpc female and male gonadal somatic cells, and adult pachytene spermatocytes.
ORGANISM(S): Mus musculus 
2008-12-16 | E-TABM-412 | biostudies-arrayexpress
TranscriptomicsRound Spermatids and Pachytene Spermatocytes
Mouse Round Spermatids (Sptd) and Pachytene Spermatocytes (Spcy)
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-1768 | biostudies-arrayexpress
ProteomicsRNA interactome capture analysis of mouse male germ cells
Mass spectrometry data of RNA interactome capture (RIC) assay for STA-PUT purified mouse primary male germ cells, including spermatogonia (SG), pachytene spermatocyte (pSC) and round spermatid (rST)
ORGANISM(S): Mus musculus (Mouse) 
2025-10-29 | PXD043074 | Pride
Spermatogonia  pachytene spermatocyte  round spermatid  mouse  rna-interactome capture  proteomics 
TranscriptomicsMAEL-dependent selective processing of pachytene piRNA precursors and translation of spermiogenic mRNAs
Piwi-interacting small RNAs (piRNAs) of fetal prospermatogonia of mice have been strongly implicated in transposon control. In contrast, little is known about biogenesis and function of abundant piRNAs from adult testes expressed in late spermatocytes and round spermatids. These so-called "pach...
ORGANISM(S): Mus musculus 
2014-07-25 | E-GEOD-50983 | biostudies-arrayexpress
TranscriptomicsAGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline
The four mammalian Argonaute family members are thought to share redundant functions in the microRNA pathway, yet only AGO2 possesses the catalytic "slicer" function required for RNA interference. Whether AGO1, AGO3, or AGO4 possess specialized functions remains unclear. Here, we Series_su...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-39652 | biostudies-arrayexpress
TranscriptomicsRicochet transcription of pachytene piRNA promoters in mammals
The origin and stability of germline noncoding RNAs remain largely uncharacterized in mammals. Here, we demonstrate that the vast majority of pachytene piRNAs originate from less than 100 bi- and unidirectionally transcribed loci in the mouse genome. These loci show features characteristic of trans...
ORGANISM(S): Mus musculus 
2015-09-01 | E-MTAB-1265 | biostudies-arrayexpress
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