patient-derived xenograft

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Unknown (3842)
Genomics (1857)
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Genomic (5)
Clinical (2)

Organisms

Homo sapiens (1566)
Mus musculus (150)
Danio rerio (3)
Canis lupus familiaris (3)
Homo sapiens/Mus musculus xenograft (2)
synthetic construct (2)
Rattus norvegicus (1)
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Fusarium sinicum (1)

Organisms

Homo sapiens (1042)
Mus musculus (69)
Homo sapiens/Mus musculus xenograft (2)
Canis lupus familiaris (2)
Cancer sp. (1)
human viral metagenome (1)
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Mus (1)
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Repository

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geo (957)
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biostudies-arrayexpress (214)
pride (105)
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PAXDB (1)

Tissue

Cell culture (33)
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Disease

Breast cancer (19)
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Melanoma (5)
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Cholangiocarcinoma (4)
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Not Available (2)
Hepatocellular carcinoma (2)
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Carcinoma (1)
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B-cell acute lymphoblastic leukemia (1)
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Head and neck squamous cell carcinoma (1)
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Luminal breast carcinoma (1)
Lung adenocarcinoma (1)
Medulloblastoma (1)
Multiple myeloma (1)
Myxoid liposarcoma (1)

Technology Type

Mass Spectrometry (105)
Shotgun proteomics (52)
Bottom-up proteomics (29)
Affinity purification coupled with mass spectrometry proteomics (16)
Data-dependent acquisition (12)
Data-independent acquisition (9)
Mass spectrometry assay (8)
Mass spectrometry (5)
Illumina HiSeq 2000 (4)
Fluorescence imaging (4)
Fluorescence intensity (4)
Top-down proteomics (4)
Mass spectrometry (3)
Gel-based experiment (3)
Illumina HiSeq 2000, ILLUMINA (2)
Chemical cross-linking coupled with mass spectrometry proteomics (2)
ABI_SOLID, Illumina HiSeq 2000, Illumina 450K, AB 5500xl Genetic Analyzer, AB 5500 Genetic Analyzer, ILLUMINA (1)
HiSeq X Ten, ILLUMINA, Illumina HiSeq 2500 (1)
ILLUMINA, Illumina HiSeq 2000 (1)
ILLUMINA, Illumina HiSeq 4000, Illumina HiSeq 2500 (1)
Illumina HiSeq 2000, Illumina MiSeq (1)
Illumina HiSeq 2500, ILLUMINA (1)
Infinium_OmniExpress-24v1.0 (1)
DNA sequencing (1)
RNA-seq (1)
Proteogenomics (1)
RNA mass spectrometry (1)
SRM/MRM (1)
SWATH MS (1)

Instrument Platform

Orbitrap Fusion Lumos (12)
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Q Exactive (10)
Illumina HiSeq 4000 (9)
Illumina HiSeq 2500 (8)
Illumina NovaSeq 6000 (8)
NextSeq 500 (8)
NextSeq 550 (4)
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Q Exactive HF (3)
Instrument (2)
Orbitrap Exploris 240 (2)
Illumina Hybridisation Oven (1)
10x Chromium Controller (1)
MoFlo Legacy cell sorter (Beckman Coulter) (1)
PC (1)
Qiagen MinElute (1)
Illumina iScan (1)
BD FACSARIA II (1)
Affymetrix GeneChip Scanner 3000 (1)
GeneChip Scanner 3000 7G (1)
Illumina Genome Analyzer IIx (1)
Illumina NovaSeq X (1)
6560 Q-TOF LC/MS (1)
LTQ Orbitrap (1)
LTQ Orbitrap XL (1)
LTQ Velos (1)
Orbitrap Eclipse (1)

Publication Date

2026 (189)
2025 (186)
2023 (153)
2024 (150)
2022 (113)
2021 (111)
2020 (78)
2015 (72)
2019 (62)
2018 (60)
2016 (59)
2014 (51)
2017 (29)
2013 (21)
2012 (15)
2011 (10)
2010 (5)
2008 (3)
2009 (2)
2005 (1)
2027 (1)

UNIPROT ID/AC

1433B_HUMAN (1)
1433E_HUMAN (1)
1433F_HUMAN (1)
1433G_HUMAN (1)
1433S_HUMAN (1)
1433T_HUMAN (1)
1433Z_HUMAN (1)
2A5A_HUMAN (1)
2A5D_HUMAN (1)
2A5E_HUMAN (1)
2A5G_HUMAN (1)
2AAA_HUMAN (1)
2AAB_HUMAN (1)
2ABA_HUMAN (1)
2ABD_HUMAN (1)
3BHS1_HUMAN (1)
3HIDH_HUMAN (1)
41_HUMAN (1)
4EBP2_HUMAN (1)
4F2_HUMAN (1)
5HT6R_HUMAN (1)
5NT3A_HUMAN (1)
5NTC_HUMAN (1)
5NTD_HUMAN (1)
6PGD_HUMAN (1)
6PGL_HUMAN (1)
8ODP_HUMAN (1)
9606.ENSP00000233596 (1)
9606.ENSP00000268624 (1)
9606.ENSP00000291295 (1)

CHEBI ID

CHEBI:111517 (1)
CHEBI:132188 (1)
CHEBI:132477 (1)
CHEBI:132479 (1)
CHEBI:132546 (1)
CHEBI:132958 (1)
CHEBI:132983 (1)
CHEBI:133028 (1)
CHEBI:133032 (1)
CHEBI:133057 (1)
CHEBI:133077 (1)
CHEBI:133139 (1)
CHEBI:133141 (1)
CHEBI:133144 (1)
CHEBI:133172 (1)
CHEBI:133186 (1)
CHEBI:133223 (1)
CHEBI:133460 (1)
CHEBI:133515 (1)
CHEBI:133559 (1)
CHEBI:133647 (1)
CHEBI:133649 (1)
CHEBI:133672 (1)
CHEBI:133677 (1)
CHEBI:133693 (1)
CHEBI:133733 (1)
CHEBI:137271 (1)
CHEBI:138368 (1)
CHEBI:138529 (1)
CHEBI:141472 (1)

Metabolite Name

1-Methylhistidine (2)
2'-O-methylcytidine (2)
2-Aminobutyric acid (2)
Anserine (2)
Creatine (2)
Glycine (2)
Kynurenine (2)
LPC(17:0/0:0) (2)
LPC(18:0/0:0) (2)
LPC(18:2/0:0) (2)
LPE(P-16:0) (2)
N1-Methyl-4-pyridone-3-carboxamide (2)
SM(d18:1/18:0) (2)
(5-L-Glutamyl)-L-Alanine (1)
(R)-3-hydroxybutyrylcarnitine (1)
(S)-¦Â-Aminoisobutyric Acid (1)
.beta.-D-Glucopyranosiduronic acid, 4-(7-hydroxy-4-oxo-4H-1-benzopyran-3-yl)phenyl (1)
1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine (1)
1,3,7-Trimethyluric Acid (1)
1,3-Dimethyluric Acid (1)
1-(1-enyl-palmitoyl)-2-arachidonoyl-GPC (P-16:0/20:4)* (1)
1-(1-enyl-palmitoyl)-2-arachidonoyl-GPE (P-16:0/20:4)* (1)
1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2)* (1)
1-(1-enyl-palmitoyl)-2-linoleoyl-GPE (P-16:0/18:2)* (1)
1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0)* (1)
1-(1-enyl-palmitoyl)-GPE (P-16:0)* (1)
1-(1-enyl-stearoyl)-GPE (P-18:0)* (1)
1-(1Z-Octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine (1)
1-(1Z-Octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine (1)
1-Docosahexaenoyl-2-stearoyl-sn-glycero-3-phosphocholine (1)

First Public Date

2026 (217)
2025 (214)
2024 (193)
2023 (161)
2022 (120)
2021 (101)
2020 (86)
2019 (75)
2018 (47)
2015 (43)
2014 (40)
2017 (36)
2016 (20)
2013 (3)

Modification

-17.026549 (1)
15.994915 (1)
42.010565 (1)

Study status

Recruiting (2)

Study type

Transcription profiling by array (112)
RNA-seq of coding RNA (39)
Methylation profiling by array (13)
Genotyping by array (7)
ChIP-seq (7)
Comparative genomic hybridization by array (6)
Human - High-throughput sequencing (4)
Cell line - High-throughput sequencing (3)
RNA-seq of coding RNA from single cells (3)
RNA-seq of non coding RNA (3)
Unknown experiment type (2)
Human - One-color microarray (2)
ATAC-seq (2)
DNA-seq (2)
Proteomic profiling by array (2)
Methylation profiling by high throughput sequencing (2)
Observational (2)
Human - Methylation microarray (1)
RNAi profiling by array (1)
MicroRNA profiling by high throughput sequencing (1)
Spatial transcriptomics by high-throughput sequencing (1)
RNA-seq of total RNA (1)

Release Date

2025 (527)
2022 (460)
2023 (450)
2021 (439)
2024 (421)
2020 (382)
2019 (312)
2018 (250)
2017 (205)
2016 (189)
2015 (154)
2026 (87)
2014 (82)
2013 (35)
2011 (21)
2012 (18)
2010 (10)
2009 (4)
2008 (3)
2005 (1)
2007 (1)

Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (6)
Baylor College of Medicine (3)
Cancer Biology Department, Fox Chase Cancer Center, Philadelphia, PA, USA (3)
Memorial Sloan Kettering Cancer Center (3)
Johns Hopkins University (2)
, Dana-Farber Cancer Institute, Harvard Medical School 360 Longwood Avenue Longwood Center, LC4117 Boston, MA 02215 (1)
1Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada 2 Snyder Institute for Chronic Diseases, Hotchkiss Brain Institute and McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada (1)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (1)
Associate Professor, Department of Pathology, Faculty of Medicine, The University of Hong Kong (1)
Biological Engineering, MIT (1)
Breast Center - Lewis, Baylor College of Medicine, Houston TX US (1)
CRUK - Beatson Institute for Cancer Research - Switchback Rd, Bearsden, Glasgow G61 1BD - United Kingdom (1)
Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA (1)
Cancer Signalling Research Group, School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, AUSTRALIA. Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, AUSTRALIA. (1)
Charles E. Foulds, Ph.D. Assistant Professor Lester and Sue Smith Breast Center Baylor College of Medicine (1)
Children's Hospital of Philadelphia (1)
Clinical Research Division, Fred Hutchinson Cancer Research Center (1)
Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, Australia (1)
Dana-Farber Cancer Institute 450 Brookline Avenue Boston, MA 02215 USA (1)
Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (1)
Department of Biology II and Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany (1)
Department of Biology, Technion–Israel Institute of Technology Haifa, Israel (1)
Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark (1)
Department of Chemistry (1)
Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan 20139, Italy (1)
Department of Human Structure and Repair, Laboratory of Experimental Cancer Research, Ghent University, Belgium3. Cancer Research Institute Ghent (CRIG), Ghent University, Belgium (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic, USA (1)
Department of Laboratory Medicine and Pathology, University of Minnesota (1)

Location

Canada (1)
France (1)

Keyword

Drug sensitivity testing (1)
Epigenetic analysis (1)
Metastatic (1)
Molecular profiling (1)
Personalized patient-derived xenografts (pPDX) (1)
Serous (1)
Triple negative (1)

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Medulloblastoma Patient-Derived Xenograft Proteomics

Proteomic and phosphoproteomic characterization of 20 orthotopic patient-derived xenograft models of medulloblastoma

ORGANISM(S): Homo sapiens (Human)

2022-09-01 | PXD035070 | Pride

A platform of patient-derived tumor xenografts (EOC-xenografts) to recapitulate the clinicopathology and genetic alterations of ovarian cancer

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. On the basis of its histopathology and molecular-genomic changes ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC-xen...

ORGANISM(S): Homo sapiens

2015-01-07 | E-GEOD-56920 | biostudies-arrayexpress

Genomic profiling of patient-derived xenografts identify high level â€œpassengerâ€ gene aberrations associated with better prognosis in non-small cell lung cancer

Patient-derived tumor xenografts (PDXs) increasingly are being used as preclinical models to study human cancers and to evaluate novel therapeutics, as they reflect clinical cancers more closely than established tumor cell lines. With >100 PDXs established from resected non-small cell lung carcinoma...

ORGANISM(S): Mus musculus

2016-10-26 | E-GEOD-68929 | biostudies-arrayexpress

Identification of tumor antigens in the HLA peptidome of patient-derived xenograft tumors in mouse

Personalized cancer immunotherapy targeting patient-specific cancer/testis (CTA) antigens and neoantigens may benefit from large-scale tumor HLA peptidome (immunopeptidome) analysis, which aims to accurately identify antigens presented by tumor cells. While significant efforts have been invested in ...

ORGANISM(S): Homo sapiens (Human)

2020-05-27 | PXD016060 | Pride

Patient derived xenograft Tumor antigen Peptidome Hla

Of mice and models: Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer

- Within ovarian cancer research, patient-derived xenograft (PDX) models recapitulate histologic features and genomic aberrations found in original tumors. However, conflicting data from published studies have demonstrated significant transcriptional differences between PDXs and original tumors, whi...

ORGANISM(S): Homo sapiens (Human)

2025-04-07 | PXD054649 | Pride

Proteogenomics Proteomics Mass spectrometry Patient-derived xenograft models (pdx) Ovarian cancer

Construction of GBM patient-derived xenograft mouse models

PRJNA857591 | ENA

Proteomic profiling of AML patient-derived xenografts across serial transplantation

This dataset contains mass spectrometry-based proteomic profiling of acute myeloid leukemia patient-derived xenograft samples collected across serial transplantation stages. The study aimed to characterize proteome remodeling associated with leukemia propagation and disease evolution in AML PDX mode...

ORGANISM(S): Homo sapiens (Human)

2026-07-20 | PXD078079 | Pride

Acute myeloid leukemia aml patient-derived xenograft pdx serial transplantation proteomics mass spectrometry leukemia stem cells

Whole DNA methylome of an extramedullary multiple myeloma patient derived orthotopic xenograft

A patient derived orthotopic xenograft (PDOX) was generated from a patient with an 53 aggressive extramedullary multiple myeloma (EMM) to study in-depth genetic and epigenetic events and drug responses related to extramedullary disease. Whole DNA methylome of the EMM PDOX was also evaluated and comp...

ORGANISM(S): Homo sapiens

2021-06-25 | E-MTAB-10654 | biostudies-arrayexpress

RNA-Seq of patient derived osteosarcoma xenograft samples

PRJNA513353 | ENA

CGH analysis of an extramedullary muletiple myeloma PDX

A patient derived orthotopic xenograft (PDOX) was generated from a patient with an aggressive EMM to study in-depth genetic and epigenetic events and drug responses related to extramedullary disease. One of these studies was the evaluation of genetic imbalances by Affymetrix Cytoscan 750K array. Th...

ORGANISM(S): Homo sapiens

2021-06-18 | E-MTAB-10630 | biostudies-arrayexpress

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