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MetabolomicsThermal Profiling Maps Multilayered Organization of the Mitochondrial Proteome

Mitochondria execute essential metabolic, biosynthetic, and signaling functions, yet the regulatory principles governing their proteome remain incompletely understood. Here, we develop a thermal proteome profiling (TPP) workflow applied directly to purified mitochondria, enabling systematic analy...

2025-12-08 | MTBLS7386 | MetaboLights
GenomicsOptimization of codon translation rates via tRNA modifications maintains proteome integrity
Optimization of codon translation rates via tRNA modifications maintains proteome integrity
PRJNA279785 | ENA
TranscriptomicsOptimization of codon translation rates via tRNA modifications maintains proteome integrity
Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome transit along a given mRNA can influence nascent chain folding, but the extent to which individual codon translation rates impact proteome integrity remains unknown. Here, we show that slower decoding of discr...
ORGANISM(S): Caenorhabditis elegans 
2015-06-04 | E-GEOD-67387 | biostudies-arrayexpress
TranscriptomicsOptimization of codon translation rates via tRNA modifications maintains proteome integrity
Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome transit along a given mRNA can influence nascent chain folding, but the extent to which individual codon translation rates impact proteome integrity remains unknown. Here, we show that slower decoding of discr...
ORGANISM(S): Caenorhabditis elegans Saccharomyces cerevisiae 
2015-06-04 | GSE67387 | GEO
UnknownOptimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity.
Not available
S-EPMC4503807 | biostudies-literature
TranscriptomicsA proteomic view on the cell biology of Staphylococcus aureus proteome
The genome sequence is the “blue-print of life”, but proteomics is required to relate this blue-print of life to the actual physiology of living cells. Because of their low complexity – only about 2.000 proteins make a Staphylococcus aureus cell viable – bacteria are excellent model systems to ident...
ORGANISM(S): Staphylococcus aureus 
2009-11-11 | E-GEOD-15060 | biostudies-arrayexpress
ProteomicsZNF524 directly interacts with telomeric DNA and supports telomere integrity
Telomeres are nucleoprotein structures at the ends of linear chromosomes. In humans, they consist of TTAGGG repeats, which are bound by dedicated proteins such as the shelterin complex. This complex blocks unwanted DNA damage repair at telomeres, e.g. by suppressing non-homologous end joining (NHEJ)...
ORGANISM(S): Homo sapiens (Human) 
2023-10-21 | PXD043084 | Pride
Trf2 Genome integrity Alt Telomeres Rap1 Znf524 Osteosarcoma 
UnknownHeterogeneity of proteome dynamics between connective tissue phases of adult tendon.
Not available
S-EPMC7217697 | biostudies-literature
UnknownTMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples.
Not available
S-EPMC7302421 | biostudies-literature
UnknownSystem-wide analyses reveal essential roles of N-terminal protein modification in bacterial membrane integrity.
Not available
S-EPMC9356101 | biostudies-literature
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