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ProteomicsComparative proteomic study on liver lipid droplets and mitochondria from mouse housed in different temperatures
Laboratory mice are standardly housed around 23ºC, setting them under chronic cold stress. Metabolic changes of liver in mice housed under thermoneutral, standard and cold temperatures remain unknown. Here we isolated lipid droplets and mitochondria from their livers for comparative proteomic study ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-07-17 | MSV000084105 | MassIVE
ProteomicsSalt and metal tolerance involves formation of guttation droplets in species of the Aspergillus versicolor complex
Three strains of the Aspergillus versicolor complex were isolated from a salty marsh at a former uranium mining site in Thuringia, Germany. The strains from a metal-rich environment were not only highly salt tolerant (up to 20% NaCl), but at the same time could sustain elevated Cs and Sr (both up to...
ORGANISM(S): Aspergillus puulaauensis 
2022-09-12 | PXD035065 | Pride
Salt stress  heavy metals  aspergillus  mycobiome  post-mining environments 
ProteomicsStress granule phase separation in stress-responsive cytosolic extract-in-oil droplets
Stress granules (SGs) are biomolecular condensates that transiently form in the cytosol when cells are exposed to potentially hazardous conditions. Illustrating the physiological relevance of SGs, dysregulation of pathways leading to their assembly or disassembly is increasingly associated with huma...
ORGANISM(S): Homo sapiens (Human) 
2026-05-19 | PXD057906 | Pride
Droplet-based Integrated stress response Microfluidics Dsrna Biomolecular condensates G3bp1 Stress granules Liquid-liquid phase separation 
ProteomicsOla1p trafficking indicates an interaction network between mitochondria, Lipid droplets and stress granules in times of stress
Protein aggregates arise naturally under normal physiological conditions, but their formation is accelerated by age or stress-induced protein misfolding. One of the proteins that accumulate upon stress in yeast cells is Ola1p, know as the “super aggregator” Using a proximity labelling approach based...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-01-26 | PXD045513 | Pride
Protein detoxification  protein aggregation  protein shuttling  stress response: lipid droplets  mitochondria  proximity labelling  turboid 
ProteomicsComparative proteomic study on liver lipid droplets and mitochondria from mouse housed in different temperatures
Laboratory mice are standardly housed around 23ºC, setting them under chronic cold stress. Metabolic changes of liver in mice housed under thermoneutral, standard and cold temperatures remain unknown. Here we isolated lipid droplets and mitochondria from their livers for comparative proteomic study ...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-02 | PXD014224 | Pride
Liver adaptation Organellar proteomics Chronic cold stress Mitochondrion Lipid droplet Thermoneutral temperature 
TranscriptomicsStress granule phase separation in stress-responsive cytosolic extract-in-oil droplets
Stress granules (SGs) are biomolecular condensates that form transiently in the cytosol of mammalian cells in response to stress. Dysregulation of their assembly or disassembly is implicated in human age-related diseases. While phase separation is the key process underlying SG assembly, understandin...
ORGANISM(S): Homo sapiens 
2026-04-24 | GSE308184 | GEO
ProteomicsA proteomics approach to study the role of lipid droplets in plant defense
Lipid Droplets (LDs), classically viewed as lipid storage particles, are recently emerging as dynamic organelles associated with stress responses and development; however, their involvement in plant immunity has been little investigated. Here we studied LDs in Arabidopsis thaliana leaves that respon...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-02-23 | PXD011499 | Pride
Lipid droplets/pseudomonas/hr-induced defense/senescence/arabidopsis 
ProteomicsPhase separation and stress granule association of SARS-CoV-2 Nucleocapsid protein
The current work identified the protein interactors of SARS-CoV-2 Nucleocapsid RNA binding protein (NCAP or N protein) in lung cancer A-549 cells, using a co-immunoprecipitation strategy, which is coupled with SILAC-based mass spec. A significant proportion of the identified NCAP interacting protein...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD023989 | Pride
Silac mass spec Ncap Nucleocapsid Sars-cov-2 
TranscriptomicsBacterial stress granule protects mRNA through ribonucleases exclusion
Membraneless droplets formed through liquid-liquid phase separation (LLPS) play a crucial role in mRNA storage, enabling organisms to swiftly respond to environmental changes. However, the mechanisms underlying mRNA integration and protection within droplets remain unclear. Here, we unravel the role...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2026-09-07 | GSE243619 | GEO
ProteomicsArabidopsis root lipid droplets are hubs for triterpenoid synthesis, and membrane homeostasis under heat stress.
Isolated LDs of the Arabidopsis mutant sdp1 tgd1 were
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-11-06 | PXD051152 | Pride
Lipid droplets Roots Arabidopsis 
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