super-enhancer - OmicsDI

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Molecular Leukemogenesis Group, German Cancer Research Center, Heidelberg, Germany Heidelberg University, Medical Faculty, Heidelberg, Germany, 6Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany (3)
School of Life Sciences, Tsinghua University, China (2)
Group Leader (CRUK Career Development Fellow) (2)
Head, Translational Antigen Discovery Lab Department of Medicine/ School of Clinical Sciences at Monash Health Monash University Level 7, TRF Building, Monash Medical Centre 246 Clayton Road Clayton VIC 3168 Australia M: +61 415126562 (1)
1 Hudson Institute of Medical Research, Clayton, VIC, Australia, 2 Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, Australia (1)
Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (1)
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Children's Hospital of Soochow University, Suzhou (1)
Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA (1)
1Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China 2Academy of Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China 3Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China (1)
faculty of biology, Technion, Haifa, Israel (1)
Department of Pathology and Cancer Center, Stony Brook University, Stony Brook, NY 11794 (1)
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Research Center for Genome & Medical Sciences, Tokyo Metropolitan Institute of Medical Science (1)
1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. 2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. 3Biological and Biomedical Sciences Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. (1)
Institute of Pediatric Research, Children's Hospital of Soochow University, Suzhou, China. (1)
Head of Proteomics Unit, CNIO, Madrid (Spain) (1)
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Children's Hospital of Philadelphia (1)
Max Planck Institute for Molecular Genetics Department of Genome Regulation Ihnestraße 63-73 14195 Berlin, Germany (1)
CNIO (1)
Hopp Children`s Cancer Center Heidelberg (KiTZ) National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Germany Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany (1)

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Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling

Here we apply integrated epigenomic and transcriptomic profiling to uncover super-enhancer heterogeneity between breast cancer subtypes, and provide clinically relevant biological insights towards TNBC. Using CRISPR/Cas9-mediated gene editing, we identify genes that are specifically regulated by TNB...

ORGANISM(S): Homo Sapiens

2021-03-04 | PXD024505 |

USP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination

Acute Myeloid Leukemia (AML) is a heterogeneous hematologic malignancy driven by genetic and epigenetic alterations, where super-enhancers (SEs) play key oncogenic roles, representing promising therapeutic targets in AML. Through H3K27ac ChIP-seq profiling of 7 AML cell lines and 13 primary samples,...

ORGANISM(S): Homo sapiens (Human)

2026-03-16 | PXD066445 | Pride

Enhancer and super-enhancer landscape in ADPKD

PRJNA836927 | ENA

A distal activin-responsive super-enhancer regulates Fshb transcription and gonadotrope differentiation

A large “gene desert” located far upstream from Fshb and Kcna4 contains several gonadotrope-specific accessible chromatin sites which, in chromatin conformation capture (3C), were seen to make distinct contacts with both genes. The region displays several features of a super-enhancer and both genes ...

ORGANISM(S): Mus musculus (Mouse)

2026-04-27 | PXD072033 | Pride

Activin Fsh Gonadotrope differentiation

Vsx2 Super-Enhancer

Identification of a bifunctional super-enhancer in retinal development

PRJEB43302 | ENA

Super-enhancer-driven CACNA2D2 is an EWSR1::WT1 signature gene encoding a diagnostic marker for desmoplastic small round cell tumor (DSRCT)

Desmoplastic small round cell tumor (DSRCT) is a highly aggressive cancer predominantly occurring in young male adolescents. It mainly arises at sites lined by mesothelium, such as the abdominal cavity, and is driven by the pathognomonic EWSR1::WT1 fusion oncoprotein. The dismal survival rates (5–20...

ORGANISM(S): Homo sapiens (Human)

2025-06-30 | PXD053786 | Pride

Super-enhancer Dsrct Proteomics Scrna-seq Cacna2d2 Ewsr1::wt1 Ihc Biomarker

Super-enhancer landscape profiling in primary colorectal carcinoma

PRJNA699855 | ENA

Super-enhancer-associated TTC8 promotes neuroblastoma progression

PRJNA779418 | ENA

Roles of super-enhancer-driven genes in T-ALL cells

PRJNA1112807 | ENA

Lineage-specific super-enhancer activates genes in a promoter-selective manner

PRJNA497314 | ENA

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