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TranscriptomicsTargeting of mitochondrial Hsp90 with Gamitrinib, G-TPP, in U251 glioblastoma cells
U251 gliolbastoma cells were treated with vehicle (DMSO) or G-TPP, a mitochondrial targeted version of 17-AAG. 6 hours after treatment RNA was harvested and subjected to microarray analysis on Human Gene 1.0 ST Array. We sought to determine a mitochdondrial gene response after targeting inhibition o...
ORGANISM(S): Homo sapiens 
2010-12-28 | E-GEOD-26313 | biostudies-arrayexpress
ProteomicsAgTU: TPP for target ID of AgTU for revealing its anticancer mechinary
TPP: thermal proteome profiling of AgTU in HeLa and NCI-H460 cells
ORGANISM(S): Homo sapiens (Human) 
2024-03-17 | PXD042400 | Pride
Tpp Orbitrap480 Hela Nci-h460 
TranscriptomicsTranscriptional profiling of Neurospora crassa conidia undergoing germling fusion: M-NM-^Tpp-1 vs WT
To study the consequences of transcription factor pp-1 deletion during vegetative cell fusion, we sequenced mRNA of WT and M-NM-^Tpp-1 conidia during a period of intense germling fusion activity . The,WT,(FGSC2489),and,M-NM-^Tpp1,strains,were,analyzed
ORGANISM(S): Neurospora crassa OR74A 
2013-08-30 | E-GEOD-50446 | biostudies-arrayexpress
ProteomicsThermal Proteome Profiling Datasets for smarTPCA
Chemical biology and the application of small molecules has proven to be a potent perturbation strategy especially for the functional elucidation of proteins, their networks and regulators. In recent years, the cellular thermal shift assay (CETSA) and its proteome-wide extension, thermal proteome pr...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD032942 | Pride
Kinase inhibitors Small molecule arranged thermal proximity coaggregation (smartpca) Tpp with temperature range (tpp-tr) or compound concentration range (tpp-ccr) Hl-60 cell line Thermal proteome profiling (tpp) 
GenomicsCombination effect of G-TPP and LXR623 on stem cell like glioma cells
Combination effect of G-TPP and LXR623 on stem cell like glioma cells
PRJNA412218 | ENA
Genomics
TPP-4-7dpf
PRJNA884104 | ENA
ProteomicsProfiling of the proteins interacting with amyloid beta peptides in clinical samples by PACTS-TPP
Analysis and identification of Aβ1-42 peptide interaction protein in clinical samples.
ORGANISM(S): Homo Sapiens 
PXD052500 |
ProteomicsProtocol for performing and analyzing TPP-TR and TPP-CCR experiments
Explore the effect of Panobinostat on the thermal stability of the proteins of the K562 cell line proteome.
ORGANISM(S): Homo sapiens (Human) 
2019-05-24 | PXD013774 | Pride
Panobinostat Tpp-tr Tpp-ccr 
TranscriptomicsTargeting of mitochondrial Hsp90 with Gamitrinib, G-TPP, in U251 glioblastoma cells
U251 gliolbastoma cells were treated with vehicle (DMSO) or G-TPP, a mitochondrial targeted version of 17-AAG. 6 hours after treatment RNA was harvested and subjected to microarray analysis on Human Gene 1.0 ST Array.
ORGANISM(S): Homo sapiens 
2010-12-28 | GSE26313 | GEO
ProteomicsIntegrated Data-Independent Acquisition and Thermal Proteome Profiling for Proteomic Characterization of Lamotrigine-Treated MCF-7 Cells
Lamotrigine, a clinically approved anticonvulsant, has recently gained interest for its potential anticancer effects. However, the molecular mechanisms underlying its activity in breast cancer remain poorly understood. Here, an integrated mass spectrometry-based proteomic strategy combining data-ind...
ORGANISM(S): Homo sapiens (Human) 
2026-06-30 | PXD070795 | Pride
Breast cancer Proteomics Lamotrigine Thermal proteome profiling (tpp) Data-independent acquisition (dia) Drug repurposing 
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