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ProteomicsSystematic identification of 20S proteasome targets
For many years, the ubiquitin-26S proteasome degradation pathway was considered the principal route for proteasomal degradation. However, it is now becoming clear that proteins can also be targeted for degradation by an ubiquitin-independent mechanism mediated by the core 20S proteasome itself. The ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-21 | PXD044399 | Pride
Disorder Degradation 20s proteasome 
Proteomics20S proteasome digestion of HeLa cell extracts
The 20S proteasome is responsible for the catalytic activity of all proteasome complexes. Structural constraints mean that only unfolded, extended polypeptide chains may enter the catalytic core of the 20S proteasome. Here we conducted a comprehensive analysis of the 20S CP substrates in-vitro. We r...
ORGANISM(S): Homo sapiens (Human) 
2018-07-30 | PXD010132 | Pride
20s proteasome digestion Heat soluble proteins 
UnknownSubunit topology of two 20S proteasomes from Haloferax volcanii.
Not available
S-EPMC141826 | biostudies-literature
Proteomics20S proteasomes exported by malaria parasite promote its growth
Mature Red Blood Cells (RBCs) lack internal organelles and canonical defense mechanisms, making them both a fascinating host cell, in general, and an intriguing choice for the deadly malaria parasite Plasmodium falciparum (Pf), in particular. While growing inside RBCs, Pf are known to secrete multip...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD018154 | Pride
Malaria Phosphorylation Proteasome 
Proteomics20S proteasomes exported by the malaria parasite promote its growth
Mature Red Blood Cells (RBCs) lack internal organelles and canonical defense mechanisms, making them both a fascinating host cell, in general, and an intriguing choice for the deadly malaria parasite Plasmodium falciparum (Pf), in particular. Pf, while growing inside its natural host, the human RBC,...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2021-02-04 | PXD023353 | Pride
Rbcs Malaria Proteasome Evs 
ProteomicsSignature activities of 20S proteasome reveal degradation of intact ubiquitin-conjugates in hypoxia
Careful removal of unwanted proteins is necessary for cell survival. The primary constitutive intracellular protease is the 26S proteasome complex, very often found in equilibrium with its catalytic core particle – the 20S subcomplex. Protein degradation by the former is tightly regulated due to pri...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD018722 | Pride
26s 20s Peptides Proteasome Hypoxia 
UnknownLysine ubiquitination and acetylation of human cardiac 20S proteasomes.
Not available
S-EPMC5094860 | biostudies-literature
UnknownCDMS Analysis of Intact 19S, 20S, 26S, and 30S Proteasomes: Evidence for Higher-Order 20S Assemblies at a Low pH†.
Not available
S-EPMC10916762 | biostudies-literature
UnknownProteomic analysis of affinity-purified extracellular proteasomes reveals exclusively 20S complexes.
Not available
S-EPMC5731941 | biostudies-literature
Unknown20S proteasomes secreted by the malaria parasite promote its growth.
Not available
S-EPMC7895969 | biostudies-literature
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