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MetabolomicsUrinary Ubiquitin-Specific Protease 2 (USP2) as a Diagnostic Biomarker for Chronic Kidney Disease: An Integrated Multi-Omics and Network Analysis
Urinary USP2 is elevated in chronic kidney disease and shows strong diagnostic performance. Integrated metabolomics and proteomics analyses identified cortisol and prostaglandin A3 as candidate mediators and linked USP2 to lipid metabolism and ferroptosis-related pathways.
2026-05-05 | MTBLS14426 | MetaboLights
ProteomicsStructural, biochemical and functional characterization of the essential host factor SETD3 in complex with the enterovirus CV-B3 2A protease
Enteroviruses cause a number of medically relevant and widespread human diseases with no approved antiviral therapies currently available. We have previously identified the actin histidine methyltransferase SETD3 as critically important for enterovirus infection through a protein-protein interaction...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD024127 | Pride
Ap-ms Host-pathogen interactions Enterovirus Setd3 2a protease 
MetabolomicsPomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs
Plant extracts are rich in bioactive compounds, such as polyphenols, sesquiterpenes, and triterpenes, which potentially have antiviral activities. As a consequence of the coronavirus disease 2019 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, thousands of...
2021-10-06 | MTBLS2309 | MetaboLights
Metabolomics13C-glucose tracing analysis of IFN-treated A549 cells expressing wild-type SARS-CoV-2 Nsp3-4 or a deISGylation-defective Nsp3-4 mutant protein

Interferon (IFN)-stimulated gene 15 (ISG15) regulates diverse cellular processes, including antiviral immunity, through its conjugation to target proteins (ISGylation). Increasing evidence suggests that ISGylation can also reshape cellular metabolism; however, how viruses counteract ISGylation-me...

2026-05-05 | MTBLS14030 | MetaboLights
UnknownEfficient Strategy to Design Protease Inhibitors: Application to Enterovirus 71 2A Protease.
Not available
S-EPMC10125330 | biostudies-literature
UnknownPicornavirus 2A protease regulates stress granule formation to facilitate viral translation.
Not available
S-EPMC5819834 | biostudies-literature
ProteomicsComplementary proteomics strategies identify the ataxin-1 interactome in Neuro-2a cells
To identify protein partners of ataxin-1 in neuronal cells under control or stress conditions, we use complementary proteomics strategies of proximity-dependent biotin identification (BioID) and affinity purification (via GFP-trap pulldown) in Neuro-2a cells expressing epitope-tagged forms of ataxin...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-18 | PXD010352 | Pride
Gfp-trap Ataxin-1 Bioid Interactome Neuro-2a Lc – msms 
UnknownThe EV71 2A protease occupies the central cleft of SETD3 and disrupts SETD3-actin interaction.
Not available
S-EPMC11099015 | biostudies-literature
ProteomicsExploratory quantitative proteomic analysis of NMN-treated and TMEV-infected Neuro-2a and RAW264.7 cells
Viral infection of the central nervous system (CNS) is linked to neurodegenerative processes, but the metabolic mechanisms influencing antiviral responses and neuroinflammation remain poorly understood. Nicotinamide adenine dinucleotide (NAD) plays a key role in mitochondrial function and immune sig...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-29 | PXD075207 | Pride
Nmn Tmev Neuroinflammation Raw264.7 Proteomics Nad metabolism Neuro-2a Lc–ms/ms 
UnknownStructure-Based Lead Optimization of Enterovirus D68 2A Protease Inhibitors.
Not available
S-EPMC11457037 | biostudies-literature
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