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MetabolomicsHydrolyzing NAD to NMN and AMP by SelO is required for mitochondria homeostasis

The regulation of mitochondrial nicotinamide adenine dinucleotide (mNAD) is crucial for numerous life processes. However, until now, no metabolic reaction responsible for downregulating mNAD has been identified. Through in silico screening of potential NAD-binding proteins, we discovered a previo...

2026-01-07 | MTBLS13624 | MetaboLights
TranscriptomicsNicotinamide mononucleotide, a key NAD+ precursor, treats the pathophysiology of diet- and age-induced diabetes
Type 2 diabetes (T2D) has become an epidemic in our modern lifestyle, likely due to calorie-rich diets overwhelming our adaptive metabolic pathways. One such pathway is mediated by nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in mammalian NAD+ biosynthesis, and the NAD+-...
ORGANISM(S): Mus musculus 
2011-12-05 | E-GEOD-31647 | biostudies-arrayexpress
ProteomicsSWATH proteomics of NMN effects
Nicotinamide mononucleotide (NMN) has emerged as a promising therapeutic intervention for age-related disorders, including Type 2 Diabetes. In this study, we investigated the effects of NMN treatment on glucose uptake and its underlying mechanisms in mouse tissues (muscle, liver, brain and adipose t...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-06-16 | PXD043257 | Pride
Dia-nn C2c12 Mouse Swath-ms Nmn Hepg2 
ProteomicsExploratory quantitative proteomic analysis of NMN-treated and TMEV-infected Neuro-2a and RAW264.7 cells
Viral infection of the central nervous system (CNS) is linked to neurodegenerative processes, but the metabolic mechanisms influencing antiviral responses and neuroinflammation remain poorly understood. Nicotinamide adenine dinucleotide (NAD) plays a key role in mitochondrial function and immune sig...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-29 | PXD075207 | Pride
Nmn Tmev Neuroinflammation Raw264.7 Proteomics Nad metabolism Neuro-2a Lc–ms/ms 
ProteomicsAge-Related Disruption of the Proteome and Acetylome in Mouse Hearts Correlates with Differential Loss of Function that is Attenuated by SS-31 and NMN
We analyzed the effects of aging on protein abundance and acetylation, as well as the ability of the mitochondrial-targeted drugs SS-31 and NMN to reverse age-related changes, in mouse hearts. Both drugs had a modest effect on restoring the abundance and acetylation of proteins that are lost with ag...
ORGANISM(S): Mus Musculus 
2022-08-02 | PXD027458 | panorama
ProteomicsA Conformation specific Nanobody Targeting the NMN-activated State of SARM1
Upon axonal injury, Sterile alpha (SAM) and Toll/interleukin-1 receptor (TIR) motif containing 1 (SARM1) is activated by nicotinamide mononucleotide (NMN) to deplete NAD and consequently promote the process of axon degeneration (AxD). Currently, only the inactive form of SARM1 in its auto-inhibitory...
ORGANISM(S): Homo sapiens (Human) 
2022-11-29 | PXD033528 | Pride
Sarm1 Adp ribosyl cyclase Xl-ms Hdx-ms 
GenomicsNMN protects cisplatin induced AKI via NAD+/SIRT1 pathway
NMN protects cisplatin induced AKI via NAD+/SIRT1 pathway
PRJNA1311443 | ENA
UnknownCharacterization of Two NMN Deamidase Mutants as Possible Probes for an NMN Biosensor.
Not available
S-EPMC8231969 | biostudies-literature
GenomicsRNA-Sequencing of Aged Mouse Oocytes with in vivo Nicotinamide Mononucleotide (NMN) Treatment
RNA-Sequencing of Aged Mouse Oocytes with in vivo Nicotinamide Mononucleotide (NMN) Treatment
PRJNA759861 | ENA
GenomicsComparation of the anti-CD19 CAR-T and the NMN treated anti-CD19 CAR-T
Comparation of the anti-CD19 CAR-T and the NMN treated anti-CD19 CAR-T
PRJNA824334 | ENA
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