A-synuclein - OmicsDI

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-- (1)
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- (1)
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UNIPROT ID/AC

P37840 (8)
P09936 (3)
O60260 (3)
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P20711 (2)
P21397 (2)
P07101 (2)
P0CG47 (2)
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ENSEMBL ID

ENSG00000170477 (2)
ENSG00000158828 (1)
ENSG00000154277 (1)
ENSG00000151552 (1)
ENSG00000116288 (1)
ENSG00000116688 (1)
ENSG00000142319 (1)
ENSG00000149295 (1)
ENSG00000213585 (1)
ENSG00000115317 (1)
ENSG00000093010 (1)
ENSG00000126602 (1)
ENSG00000180176 (1)
ENSG00000198074 (1)
ENSG00000111275 (1)
ENSG00000145335 (1)
ENSG00000112062 (1)
ENSG00000077721 (1)
ENSG00000132437 (1)
ENSG00000185345 (1)
ENSG00000033178 (1)
ENSG00000229353 (1)
ENSG00000247315 (1)

CHEBI ID

CHEBI:15422 (6)
CHEBI:16761 (5)
CHEBI:18243 (3)
CHEBI:41941 (3)
CHEBI:18421 (2)
CHEBI:29034 (2)
CHEBI:29033 (2)
CHEBI:27978 (2)
CHEBI:15765 (2)
CHEBI:16908 (2)
CHEBI:15846 (2)
CHEBI:17895 (2)
CHEBI:15377 (2)
CHEBI:15379 (2)
CHEBI:26523 (2)
CHEBI:25806 (1)
CHEBI:17963 (1)
CHEBI:641 (1)
CHEBI:13390 (1)
CHEBI:59560 (1)
CHEBI:36080 (1)
CHEBI:20680 (1)
CHEBI:28770 (1)
CHEBI:545959 (1)
CHEBI:16389 (1)
CHEBI:15356 (1)
CHEBI:24432 (1)
CHEBI:32952 (1)
CHEBI:50910 (1)
CHEBI:60027 (1)

Metabolite Name

Methanol (3)
Glycine (3)
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Acetone (3)
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Formate (2)
Ascorbate (2)
Acetate (2)
GTP (2)

First Public Date

2026 (60)
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2014 (27)
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2018 (4)
2016 (3)
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2013 (2)

Modelling Approach

Ordinary differential equation model (8)

Lab affiliation

Paris-Saclay Institute of Neuroscience, Team Melki, CNRS, Gif-sur-Yvette, France (8)
IMSB, ETH Zurich (4)
Fondazione Ri.MED (3)
Ruhr University Bochum, Medical Faculty, Medizinisches Proteom-Center (3)
Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana 47907, United States (2)
CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India (2)
DZNE Munich, Neuroproteomics, Feodor-Lynen-Str. 17, 81377 München, Germany (2)
Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, United States (2)
Department of Neurology Institute for Cell Engineering Johns Hopkins University School of Medicine (2)
Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland. (2)
Institute of Molecular Systems Biology, ETH Zurich (2)
Principal Scientist, CSIR- Centre for Cellular and Molecular Biology, Hyderabad, India (2)
Rush University Medical Center (2)
1. German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany 2. Department of Neurology, University Clinic Ulm, 89081 Ulm, Germany (1)
1. Institute of Clinical Chemistry, University Medical Center Goettingen, Goettingen, Germany; 2. Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany (1)
1. Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Department of Neurology, Fuzhou 350108, China 2.School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China (1)
1Human Embryonic and Induced Pluripotent Stem Cell Unit, Hellenic Pasteur Institute, Athens, Greece 2Laboratory of Cellular and Molecular Neurobiology-Stem Cells, Hellenic Pasteur Institute, Athens, Greece (1)
Appel Alzheimer's Disease Research Institute & Brain and Mind Research Institute Weill Cornell Medicine New York, NY USA (1)
Assisstant professor. Graduate College. Rush University Medical Center. (1)
Assistant Professor of Genetics Genetics Department University of Pennsylvania 5050 Colket Translational Research Building 3501 Civic Center Boulevard Philadelphia, PA 19104 (1)
Associate Professor of Neurology and Neuroscience (1)
Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom (1)
Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA. (1)
Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA. (1)
Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA (1)
Bioinformatics Scientist Van Andel Institute (1)
Biomedical Research Foundation Academy of Athens- BRFAA, Centre of Basic Research, Athens, Greece (1)
Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece. (1)
Biozentrum, University of Basel, Switzerland. (1)
Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana 47907, United States (1)

IsPrivate

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Model Flag

Non Kinetic (2)

Classification

fungi (1)

Modification

Not available (2)

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Transcription profiling by array (46)
RNA-seq of coding RNA (8)
RNA-seq of coding RNA from single cells (3)
RNA-seq of non coding RNA (3)
Comparative genomic hybridization by array (2)
Single nucleus RNA sequencing (2)
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The responses of astrocytes stimulated by extracellular a-synuclein

Abnormal neuronal aggregation of a-synuclein is implicated in the development of Parkinson’s disease. Glial cells also show extensive a-synuclein pathology and are thought to contribute to disease progression. However, the mechanism that produces the glial a-synuclein pathology and the interaction b...

ORGANISM(S): Rattus norvegicus

2010-01-11 | E-GEOD-11574 | biostudies-arrayexpress

The Parkinson's disease protein alpha-synuclein is a direct modulator of Processing-bodies and mRNA stability

Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR,Carr SA, de Jager P, Myers CL, Lindquist S, Greenmyre TJ, Bartel DP, Feany MB, Sunyaev S, Chung CY and Khurana V. Alp...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2022-03-09 | MSV000089026 | MassIVE

Neuronal identity defines a-synuclein and tau toxicity

PRJNA926993 | ENA

Expression data from oligodendroglial cell line

Coexpression of alpha-synuclein and p25alpha in an oligodendroglial cell line elicites a degenerative response that relies on aggregation and phosphorylation of alpha-synuclein at Ser129 We used microarray analysis to detail the changes in gene expression caused by alpha-synuclein aggregation follow...

ORGANISM(S): Rattus norvegicus

2013-10-28 | E-GEOD-51781 | biostudies-arrayexpress

Microarray analysis of an synthetic a-synuclein induced cellular model

PRJNA493614 | ENA

Beta-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins

Previous studies have demonstrated an importance of alpha-synuclein as a modulator of various mechanisms implicated in chemical neurotransmission but information about other two synuclein family members’ involvement in molecular processes taking place in presynaptic terminals is limited. Here we dem...

ORGANISM(S): Mus musculus (Mouse)

2022-02-17 | PXD027786 | Pride

Development of a method for the quantification of tyrosine 39 phosphorylated alpha-synuclein in human cerebrospinal fluid

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder caused by dopaminergic neuronal deaths. For a proper treatment of PD, biomarkers that would enable us to monitor disease progression or responses to a disease-modifying agent, or that can be used as a presymptomatic mar...

ORGANISM(S): Homo sapiens (Human)

2020-05-26 | PXD012202 | Pride

Parkinson's disease Parallel reaction monitoring Enrichment Alpha-synuclein Phosphotyrosine

Human microglia remove intraneuronal a-synuclein aggregates in a stem cell model of Parkinson’s disease

PRJNA1228566 | ENA

An In Vivo Model of a-Synuclein Spread from Gut to Brain

PRJNA1401831 | ENA

Chemical Crosslinking of Isotopically Labeled α-Synuclein Reveals Structural Changes and the Interface of Oligomeric Species

Due to its high pharmaceutical relevance, α-synuclein is one of the best studied intrinsically disordered proteins to date. Its structural plasticity reaches from α-helical when bound to membranes through disordered in solution to β-sheet when forming amyloid fibrils. Recently the possible toxicity ...

ORGANISM(S): Homo sapiens (Human)

2023-04-07 | PXD027349 | Pride

Human Cross-linking mass spectrometry Α-synuclein

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