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ProteomicsC4PR_LIV: N-terminomic analysis of SARS-CoV-2-infected ACE2-A549 cells (Enriched)
Many events in viral infection are regulated through post-translational modification. In the case of positive-sense RNA viruses such as SARS-CoV-2 which encodes two viral proteases, proteolytic cleavage of both viral and cellular proteins is crucial for productive viral infection. In this work we st...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD021152 | Pride
Tmtpro Sars-cov-2 Ace2-a549 Covid-19 N-terminomics 
ProteomicsC4PR_LIV: N-terminomic analysis of SARS-CoV-2-infected ACE2-A549 cells (Unenriched)
Many events in viral infection are regulated through post-translational modification. In the case of positive-sense RNA viruses such as SARS-CoV-2 which encodes two viral proteases, proteolytic cleavage of both viral and cellular proteins is crucial for productive viral infection. In this work we st...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD021145 | Pride
C4pr_liv: n-terminomic analysis of sars-cov-2-infected ace2-a549 cells (unenriched) 
ProteomicsC4PR_LIV: N-terminomic analysis of SARS-CoV-2-infected ACE2-A549 cells (Enriched - Variable search)
Many events in viral infection are regulated through post-translational modification. In the case of positive-sense RNA viruses such as SARS-CoV-2 which encodes two viral proteases, proteolytic cleavage of both viral and cellular proteins is crucial for productive viral infection. In this work we st...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD021402 | Pride
Tmtpro Sars-cov-2 Ace2-a549 Covid-19 N-terminomics 
ProteomicsDecipering the molecular mechanism of ACE2 regulating A549 cells
In the current study, using a lentivirus-based expression system in lung cancer cells (A549), we show that ACE2 overexpression reduces the viability and migratory potential of cancer cells, highlighting the robust anti-tumorigenic effects of ACE2 function. Moreover, a quantitative proteome-level com...
ORGANISM(S): Homo Sapiens 
2021-03-22 | PXD024899 |
ProteomicsPhosphoproteome, ubiquitinome and full proteome analysis at 6 and 24 hours post SARS-CoV-2 infection in A549-ACE2 cells
A549-ACE2 cells were mock or SARS-CoV-2 infected (multiplicity of infection: 3) for 6 or 24 h and subjected to full proteome, phosphoproteome and ubiquitinome analysis using data-dependent acquisition LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2020-07-14 | PXD020019 | Pride
Sars-cov-2  infected proteome  phosphoproteome  ubiquitinome  a549-ace2 
ProteomicsConcomitant targeting of viral and host methyltransferases is essential for attenuating SARS-CoV-2
LC-MS/MS based investigation of protein abundance changes, induced by DZNep treatment in A549-ACE2 cell line (0.75 uM DZNep, vehicle PBS; 6h pre-treatment, harvested 24 h.p.i. with mock/SARS-CoV/SARS-CoV-2 at MOI 3) or primary human bronchial epithelial cells (NHBEs) (1.5 uM DZNep, vehicle PBS; 6h p...
ORGANISM(S): Homo sapiens (Human) 
2022-06-28 | PXD034361 | Pride
Dznep Sars-cov-2 A549 Nhbe Tubercidin A549-ace2 
GenomicsSARS-CoV-2 infected and uninfected VeroE6 and A549-ACE2: Bemcentinib and liposome treatments
SARS-CoV-2 infected and uninfected VeroE6 and A549-ACE2: Bemcentinib and liposome treatments
PRJNA741531 | ENA
ProteomicsTime-based quantitative proteomic and phosphoproteomic analysis of A549-ACE2 cells during SARS-CoV-2 infection
The outbreak of COVID-19, a disease caused by severe acute respiratory syndrome coronavirus 2, led to an ongoing pandemic with devastating consequences for the global economy and human health. With the globalspread of SARS-CoV-2, multidisciplinary initiatives were launched to explore new diagnostic,...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053240 | Pride
Proteomics Virus-host interaction Sars-cov-2 Covid-19 
GenomicsMicro-array analysis of SARS-CoV2 treated Calu3 and A549-ACE2 cells
Micro-array analysis of SARS-CoV2 treated Calu3 and A549-ACE2 cells
PRJNA781486 | ENA
TranscriptomicsSARS-CoV-2 infected and uninfected VeroE6 and A549-ACE2: Bemcentinib and liposome treatments
VeroE6 or A549-ACE2 cells were treated with inhibitors of phosphatidylserine receptors and infected with SARS-CoV-2.
ORGANISM(S): Chlorocebus aethiops Homo sapiens Severe acute respiratory syndrome coronavirus 2 
2021-06-26 | GSE178942 | GEO
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