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MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
TranscriptomicsTranscription profiling of lymph node T cells isolated from Ezh2fl/fl or Ezh2 deficient mice to study the role of ezh2 on actin polymerization and cell signaling
Lymph node T cells isolated from Ezh2fl/fl or Ezh2 deficient mice
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-1566 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles in naïve WT and Asc-null bone marrow derived dendritic cells
The adaptor protein ASC contributes to innate immunity through the assembly of caspase-1-activating inflammasome complexes. We demonstrate that ASC plays an inflammasome-independent cell-intrinsic role in adaptive immune cells. Asc-/- mice displayed defective antigen presentation by dendritic cells ...
ORGANISM(S): Mus musculus 
2012-07-08 | E-GEOD-30769 | biostudies-arrayexpress
ProteomicsParallel kinase pathways stimulate actin polymerization at depolarized mitochondria
Mitochondrial damage (MtD) represents a dramatic change in cellular homeostasis, necessitating metabolic changes and stimulating mitophagy. One rapid response to MtD is rapid peri-mitochondrial actin polymerization, termed ADA (acute damage-induced actin). The activation mechanism for ADA is unknown...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-15 | PXD031699 | Pride
Rac gef Mefs Phosphoproteomics Actin Mitochondria Cdc42 gef 
TranscriptomicsChip-seq of EZH2 and VAV1 in 24hr differentiated Th1 and Th2 cells with or without EZH2 or Actin polymerization inhibitors
CD4 T helper cells can differentiate to several types of cells like Th1, Th2, Th17 and Treg. This process is directed by cytokines and activation of T cells by specific antigens. This process has its own plasticity and it is directed by epigenetic changes allowing cells to develop and differentiate....
ORGANISM(S): Mus musculus 
2021-08-28 | E-MTAB-9524 | biostudies-arrayexpress
ProteomicsEvolutionarily Convergent Mechanism of Formin Regulation Coordinates Actin Polymerization in Apicomplexan Parasites
Apicomplexan parasites rely on actin-based motility for host cell invasion and for their dissemination. Although previous studies implicate formin 1 (FRM1) in governing this process in Toxoplasma, the mechanisms that position it at the cell apex and regulate its activity during the transition from i...
ORGANISM(S): Toxoplasma gondii ME49 
2025-11-04 | PXD068228 | Pride
Methylation Gliding motility Intramolecular regulation Autoinhibition Actin polymerization Formin 
TranscriptomicsGenomic Comparison of the O-antigen Biosynthesis Gene Clusters of E. coli O55 Strains Belonging to Three Lineages.
Typical enteropathogenic Escherichia coli (EPEC) O55:H7 is regarded as the closest relative of enterohemorrhagic E. coli (EHEC) O157:H7. Both serotypes usually express the γ1 intimin subclass and trigger actin polymerazation by the Tir-TccP pathway. However, atypical O55:H7 strains capable of trigg...
ORGANISM(S): Escherichia coli 
2010-05-22 | E-GEOD-8889 | biostudies-arrayexpress
GenomicsControl of plasma membrane-associated actin polymerization specifies the pattern of the cell wall in xylem vessels.
Control of plasma membrane-associated actin polymerization specifies the pattern of the cell wall in xylem vessels.
PRJNA1207997 | ENA
GenomicsMKL1 deficiency results in a severe neutrophil motility defect due to impaired actin polymerization
MKL1 deficiency results in a severe neutrophil motility defect due to impaired actin polymerization
PRJNA555994 | ENA
ProteomicsMKL1 deficiency results in a neutrophil motility defect with impaired actin polymerization and excessive degranulation
Megakaryoblastic leukemia 1 (MKL1) promotes the regulation of essential cell processes, including actin cytoskeletal dynamics by co-activating serum response factor. Recently, the first human case with MKL1 deficiency has been identified, leading to a novel primary immunodeficiency. We report a seco...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD014633 | Pride
Mkl1 Actin poymerization Neutrophils Srf Mrtf-a 
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