Sort   by:  
 Page size 
MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
MetabolomicsComparative metabolomics of Mycoplasma bovis and Mycoplasma gallisepticum reveals fundamental differences in active metabolic pathways and suggests novel gene annotations
Mycoplasmas are simple, but successful parasites that have the smallest genome of any free-living cell and are thought to have a highly streamlined cellular metabolism. Here we have undertaken a detailed metabolomic analysis of two species, Mycoplasma bovis and Mycoplasma gallisepticum, which cause ...
2017-10-10 | MTBLS535 | MetaboLights
GenomicsHydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster
This SuperSeries is composed of the following subset Series: GSE32362: Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster (Illumina HumanMethylation450 BeadChip) GSE33129: Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mamm...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-33130 | biostudies-arrayexpress
TranscriptomicsHydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster (Infinium HumanMethylation450 Beadchip)
Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of activated lineage-specific genes. Here we used the mammalian Hoxa cluster of developmental genes as a model system to follow changes in DNA modif...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-32362 | biostudies-arrayexpress
GenomicsHistone acetylation H2BK20ac marks cell-state specific active regulatory elements
Histone acetylation H2BK20ac marks cell-state specific active regulatory elements
PRJNA295265 | ENA
TranscriptomicsMapping and analysis of chromatin state dynamics in nine human cell types (gene expression)
Chromatin profiling has emerged as a powerful means for annotating genomic elements and detecting regulatory activity. Here we generate and analyze a compendium of epigenomic maps for nine chromatin marks across nine cell types, in order to systematically characterize cis-regulatory elements, their ...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-26312 | biostudies-arrayexpress
ProteomicsDelineating changing partners of Akt1 protein as a function of its active state in HEK-293 Cells
Akt1 is a multi-functional protein, implicated and activated in multiple human solid tumors. Functional diversity of Akt1 is a result of its interactions with other proteins; which changes with changing context. This study was designed to capture the dynamics of Akt1 Interactome as a function of its...
ORGANISM(S): Homo sapiens (Human) 
2017-03-02 | PXD005976 | Pride
Apms Silac Akt1 Interactome 
ProteomicsCross-Link of active PhK and GP
Phosphorylase kinase (PhK) phosphorylates GP to initiate glycogenolysis. To gain insights into the mechanism of PhK catalyzing GP phosphorylation, we have tried a variety of methods to obtain the hPhK-GP complex, but none of them were successful. Eventually, we decided to employ XL-MS to investigate...
ORGANISM(S): Hordeum vulgare (Barley) 
2025-05-07 | PXD059369 | Pride
Phk Active state Gp Xl-ms 
GenomicsThe histone variant H3.3 promotes the active chromatin state to repress flowering in Arabidopsis
The histone variant H3.3 promotes the active chromatin state to repress flowering in Arabidopsis
PRJNA704540 | ENA
GenomicsHydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster (MeDIP-Seq)
Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of activated lineage-specific genes. Here we used the mammalian Hoxa cluster of developmental genes as a model system to follow changes in DNA modif...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-33129 | biostudies-arrayexpress
Sort   by:  
 Page size