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ProteomicsThe proteome of acute muscle pain: Observations from acute hypertonic saline induced pain in humans
Despite widespread use of experimental acute pain models to mimic chronic pathologies, little exploration has been undertaken on the acute pain proteome in humans. We re-solved to explore molecular alterations evoked by acute bouts of hypertonic saline (HS) induced muscle pain and map the spread of...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD070131 | Pride
Human Untargeted proteomics Acute pain Nociception 
Transcriptomicsnuclear calcium regulated genes in spinal neurons during inflammatory pain
Identification of a pain-associated, nuclear calcium-regulated gene program in spinal excitatory neurons during inflammatory pain, using a nucleus-specific calcium signal perturbation strategy in vivo complemented by gene profiling
ORGANISM(S): Mus musculus 
2013-12-13 | E-MTAB-1416 | biostudies-arrayexpress
MetabolomicsLipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia
Early diagnosis of acute community-acquired pneumonia (CAP) is important in patient triage and treatment decisions. To identify biomarkers that distinguish patients with CAP from non-CAP controls, we conducted an untargeted global metabolome analysis for plasma samples from142 patients with CAP (CAP...
2016-08-11 | MTBLS354 | MetaboLights
MetabolomicsThe integration of network pharmacology and multiomics reveals the mechanism by which Malus hupehensis leaves inhibit acute liver injury

Objective: The leaves of Malus hupehensis (MH) are a medicinal and edible traditional Chinese medicine (TCM) with good liver protection, although its underlying mechanism remains unclear. In this study, a network pharmacology-integrated multi-omics method was used to explore the hepatoprotective ...

2026-05-01 | MTBLS13219 | MetaboLights
TranscriptomicsTranscription profiling of rat Postnatal developmental changes in Sprague-Dawley animals in the model of neuropathic pain - spare nerve injury
Neuropathic pain is an apparently spontaneous experience triggered by abnormal physiology of the peripheral or central nervous system, which evolves with time. Neuropathic pain arising from peripheral nerve injury is characterized by a combination of spontaneous pain, hyperalgesia and allodynia. The...
ORGANISM(S): Rattus norvegicus 
2010-01-30 | E-GEOD-15041 | biostudies-arrayexpress
GenomicsTranslatome analysis reveals altered spinal astrocyte metabolism in acute and chronic pain
Translatome analysis reveals altered spinal astrocyte metabolism in acute and chronic pain
PRJNA1256508 | ENA
GenomicsAcute Inflammatory Response via Neutrophil Activation Protects Against the Development of Chronic Pain
Acute Inflammatory Response via Neutrophil Activation Protects Against the Development of Chronic Pain
PRJNA736882 | ENA
UnknownAAAPT Diagnostic Criteria for Acute Low Back Pain with and Without Lower Extremity Pain.
Not available
S-EPMC8453619 | biostudies-literature
ProteomicsMouse DRG incision injury versus sham_DIA-MS
Acute pain after surgery is still managed insufficiently. One major need is, therefore, the identification of new targets specifically relevant for postoperative pain to develop effective and non-addictive analgesics. To this end, we have used the plantar incision model in male mice and DIA-MS to re...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022706 | Pride
Pain Dia-ms Drg Incision injury 
TranscriptomicsTranscription profiling of mouse dorsal root ganglia after diphtheria-toxin deletion of the Nav1.8-expressing cells using the cre/loxP system
Comparison of transcript levels after diphtheria-toxin deletion of the Nav1.8-expressing cells using the cre/loxP system.
Pain requires input from nociceptors which are specialised peripheral sensory neurons in dorsal root ganglia (DRG). To explore the nociceptor-specific mRNA profiles, we used ...
ORGANISM(S): Mus musculus 
2008-08-02 | E-MEXP-1622 | biostudies-arrayexpress
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