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ProteomicsProfiling Tryptophan Catabolites of Human Gut Microbiota and Acute-Phase Protein Levels in Neonatal Dried Blood Specimens
National screening programs use dried blood specimens to detect abnormal metabolism or aberrant protein function in infants shortly after birth, thus identifying disorders that are not clinically evident in the newborn period. Gut microbiota metabolites and immunological acute phase proteins are cap...
ORGANISM(S): Homo Sapiens 
2022-08-02 | PXD027606 | panorama
TranscriptomicsInflammation-induced acute phase response in skeletal muscle and critical illness myopathy
Objectives: Systemic inflammation is a major risk factor for critical-illness myopathy (CIM) but its pathogenic role in muscle is uncertain. We observed that interleukin 6 (IL-6) and serum amyloid A1 (SAA1) expression was upregulated in muscle of critically ill patients. To test the relevance of the...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-53702 | biostudies-arrayexpress
TranscriptomicsHepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function
Acute phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation. Despite vast pro- and anti-inflammatory properties ascribed to individual APPs, their collective function during infections remains poorly defined. U...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-22009 | biostudies-arrayexpress
ProteomicsInterval-based secretomics unravels the time-dependent acute phase response in hepatocyte model systems
Mass spectrometry based secretomics approaches preferentially utilize serum-free culture conditions to circumvent serum induced interference and enable sufficient analytical depth. However, this negatively affects a wide range of cellular functions and thus reduces the biological relevance. Moreover...
ORGANISM(S): Homo sapiens (Human) 
2022-05-04 | PXD027821 | Pride
Il1b Heparg Shedding Secretomics Liver Acute-phase response Interval-based secretomics Il6 Hepg2 
ProteomicsProteomic analysis of septic renal acute phase response
Sepsis-induced acute kidney injury (AKI) is the most common form of AKI with poor outcomes. Renal proteomic analysis after bacterial lipopolysaccharide (LPS) administration revealed that the local renal acute phase reaction (APR) is one of the strongest responses of the kidney during septic AKI in m...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-08 | PXD014664 | Pride
Lipopolysaccharide Mouse Sepsis Kidney Lc-ms/ms 
ProteomicsMultiplex assay for quantification of acute phase proteins and immunoglobulin A in dried blood spots
Inflammation is the first line defense mechanism against infection, tissue damage or cancer development. However, inappropriate inflammatory response may also trigger diseases. The quantification of inflammatory proteins is essential to distinguish between harmful and beneficial immune response. Cur...
ORGANISM(S): Homo Sapiens 
2018-12-05 | PXD011944 | panorama
GenomicsTranscriptome profiling of the hepatic acute-phase response in LPS-treated dHepaRG cells.
Transcriptome profiling of the hepatic acute-phase response in LPS-treated dHepaRG cells.
PRJNA958246 | ENA
ProteomicsSERUM PROTEOMICS OF Experimental MALARIA-associated ARDS REVEALS A REGULATION OF ACUTE PHASE RESPONSE PROTEINS
Malaria is a parasitic infectious disease considered a public health problem. Acute respiratory distress syndrome (ARDS) is a complication in malaria-infected individuals with a high mortality rate (80% to 100%) and can occur before, during, or after antimalarial drug treatment. Although inflammatio...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-13 | PXD050496 | Pride
Biomarkers Malaria Acute resipratory distress syndrome Proteomics 
ProteomicsProteomic Profiles of Exosomes of Septic Patients Presenting to the Emergency Department Compared to Healthy Controls
Background: Septic Emergency Department (ED) patients provide a unique opportunity to investigate early sepsis. Recent work focuses on exosomes, nanoparticle-sized lipid vesicles (30-130nm) that are released into the bloodstream to transfer its contents (RNA, miRNA, DNA, protein) to other cells. Lit...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-06-29 | MSV000085646 | MassIVE
GenomicsAcute multi-level response to defective de novo chromatin assembly in S-phase
Acute multi-level response to defective de novo chromatin assembly in S-phase
PRJNA1092098 | ENA
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