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ProteomicsProteomic analysis of integrin-associated adhesion complexes isolated from cells treated with DMSO or FAK inhibitor
Human foreskin fibroblast cells were spread on fibronectin (FN) for 1 h and treated with DMSO or FAK inhibitor (3 uM, AZ13256675 (termed AZ675 for short)) for 1 h. Integrin-associated adhesion complexes isolated from these cells were analysed by mass spectrometry to determine changes in adhesion com...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-23 | MSV000080089 | MassIVE
ProteomicsProteomic analysis of integrin-associated adhesion complexes isolated from cells treated with DMSO or FAK inhibitor
Human foreskin fibroblast cells were spread on fibronectin (FN) for 1 h and treated with DMSO or FAK inhibitor (3 uM, AZ13256675 (termed AZ675 for short)) for 1 h. Integrin-associated adhesion complexes isolated from these cells were analysed by mass spectrometry to determine changes in adhesion com...
ORGANISM(S): Homo sapiens (Human) 
2016-02-02 | PXD002720 | Pride
Proteomics Ms Adhesion Focal adhesion kinase (fak) Integrin 
ProteomicsProteomic analysis of integrin adhesion complex assembly
To explore the dynamics of integrin adhesion complex assembly, isolated adhesion complexes from K562 cells were subjected to mass spectrometry based proteomic analysis. K562 cells were incubated with FN-coated beads for 1, 7 and 30 minutes and protein complexes stabilised for 2 minutes with DTBP cro...
ORGANISM(S): Homo sapiens (Human) 
2015-10-14 | PXD002159 | Pride
Human Integrins Time course K562 cells 
ProteomicsProteomic analysis of integrin adhesion complex disassembly induced by nocodazole
To explore the dynamics of integrin adhesion complex disassembly, isolated adhesion complexes from U2OS cells were subjected to mass spectrometry based proteomic analysis. U2OS cells were allowed to spread on FN, treated with nocodazole for 4 hours to disrupt microtubules. To coordinate microtubule-...
ORGANISM(S): Homo sapiens (Human) 
2015-10-14 | PXD002129 | Pride
Human Integrins U2os cells Time course 
ProteomicsProteomic characterisation of microtubule-dependent modulation of adhesion complexes
Investigating the effect of microtubule disruption by nocodazole treatment on isolated adhesion complexes.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079926 | MassIVE
ProteomicsProteomic characterisation of microtubule-dependent modulation of adhesion complexes
Investigating the effect of microtubule disruption by nocodazole treatment on isolated adhesion complexes.
ORGANISM(S): Homo sapiens (Human) 
2015-01-30 | PXD001183 | Pride
Lc-msms Adhesion complexes Nocodazole 
ProteomicsProteomic analysis of integrin adhesion complex-mediated mechanotransduction
Integrin adhesion complexes were isolated from mouse fibroblasts treated with or without blebbistatin. Adhesion complexes were resolved by SDS-PAGE, digested with trpysin and analysed by LC-MS/MS using an LTQ Velos mass spectrometer
ORGANISM(S): Mus musculus (Mouse) 
2015-10-19 | PXD000018 | Pride
Adhesion complex Mouse Integrin Fibroblast Lc-ms/ms 
TranscriptomicsEarly Dysregulation of Cell Adhesion and Extracellular Matrix Pathways in Breast Cancer Progression
Proliferative breast lesions, such as simple ductal hyperplasia (SH) and atypical ductal hyperplasia (ADH), are candidate precursors to ductal carcinoma in situ (DCIS) and invasive cancer. To better understand their relationship to more advanced disease, we used microdissection and DNA microarrays t...
ORGANISM(S): Homo sapiens 
2009-09-08 | E-GEOD-16873 | biostudies-arrayexpress
TranscriptomicsDifferential expression between frb1 mutant Arabidopsis and wild-type
Cell adhesion in plants is mediated predominantly by pectins, a group of complex cell wall associated polysaccharides. An Arabidopsis mutant, friable1 (frb1), was identified through a screen of T-DNA insertion lines that exhibited defective cell adhesion. Interestingly, the frb1 plants displayed bot...
ORGANISM(S): Arabidopsis thaliana 
2011-07-29 | E-GEOD-31033 | biostudies-arrayexpress
TranscriptomicsAnalysis of extracellular matrix and adhesion molecules expression in ALL cell line
The acute lymphoblastic leukemia cells lines JM-1, REH, Nalm-27, and SUP-B15 were analyzed for baseline expression of extacellular matrix and adhesion molecules using a pathway focused cDNA microarray (SABiosciences). RNA isolated from the ALL cell lines JM-1, REH, Nalm-27, and SUP-B15 was analyzed ...
ORGANISM(S): Homo sapiens 
2010-05-01 | E-GEOD-18516 | biostudies-arrayexpress
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