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ProteomicsProfiling of Methylglyoxal Blood Metabolism and Advanced Glycation End-Product Proteome using a Chemical Probe
Methylglyoxal (MG) is a toxic byproduct of the glycolytic pathway and is quantitatively the most important precursor to advanced glycation end-products (AGEs). Insight into which proteins and in particular their individual modification sites are central to understand the involvement of MG and AGE in...
ORGANISM(S): Homo sapiens (Human) 
2019-07-31 | PXD011314 | Pride
Human Erythrocytes Plasma Methylglyoxal 
TranscriptomicsDifferential Expression of Ove26(Diabetic) vs FVB(Nondiabetic) mice
Objective – Previous studies showed that genetic deletion or pharmacological blockade of the Receptor for Advanced Glycation Endproducts (RAGE) prevents the early structural changes in the glomerulus associated with diabetic nephropathy (DN). To overcome limitations of mouse models that lack the pr...
ORGANISM(S): Mus musculus 
2011-02-22 | E-GEOD-20844 | biostudies-arrayexpress
UnknownA novel monoclonal antibody targeting carboxymethyllysine, an advanced glycation end product in atherosclerosis and pancreatic cancer.
Not available
S-EPMC5805250 | biostudies-literature
TranscriptomicsPlatelet-secreted microRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor
Platelets contain abundant miRNAs, however, the biogenesis pathway of miRNAs in anucleate platelets is unclear. Platelet-rich plasma was diluted in washing buffer and the platelet suspension was centrifuged to isolated pure platelets.Finally, platelets were recovered in suspension buffer at the conc...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-51453 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Advanced glycation end products treated ligament cells
Ossification of the posterior longitudinal ligament (OPLL) is formed by heterogeneous ossification of posterior longitudinal ligament. The patho-mechanism of OPLL is still largely unknown. Recently, disorders of metabolism are thought to be the center of many diseases such as OPLL. Advanced glycati...
ORGANISM(S): Homo sapiens 
2016-02-16 | E-GEOD-65952 | biostudies-arrayexpress
TranscriptomicsAger (Rage) and Myd88 deletion in resected mouse livers
The effect of resection of mouse livers on survival serve as a model for the effect of resection of human livers, which are performed for both the purposes of removing sick tissue and for transplanting healthy tissue. When less than 70% of a mouse liver is resected, the mouse usually lives. However,...
ORGANISM(S): Mus musculus 
2012-06-25 | E-GEOD-22873 | biostudies-arrayexpress
UnknownLysine-arginine advanced glycation end-product cross-links and the effect on collagen structure: A molecular dynamics study.
Not available
S-EPMC8048459 | biostudies-literature
ProteomicsHuman holo-transferrin glycation
Understanding the effect of glycation on the function of transferrin, the systemic iron transporter, is fundamental to fully grasp the mechanisms leading to the loss of iron homeostasis observed in diabetes mellitus (DM). The spontaneous reaction with protein amino groups is one of the main causes o...
ORGANISM(S): Homo sapiens (Human) 
2018-05-30 | PXD009345 | Pride
Post-translational modification Holo-transferrin Blood serum Glycation Lc-ms/ms 
UnknownAdvanced glycated end-products modified transferrin mediates oxidative stress and ferroptosis in podocytes via advanced glycation end-product receptor in vitro.
Not available
S-EPMC12602698 | biostudies-literature
ProteomicsPitfalls and Solutions in Mass Spectrometry-based Identification of Protein Glycation
Protein glycation is a type of post-translational modification (PTM) involving complex non-enzymatic reactions of reducing sugars or reactive dicarbonyls with proteins, generating a heterogeneous group of advanced glycation end-products (AGEs) such as carboxymethyllysine (CML). In bottom-up proteomi...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-01-24 | PXD032235 | Pride
Cam Post-translational modification Human Iaa N-isopropylcarbamidoethylation Nipam Cm Cml Cell line Q-exactive N-isopropylacrylamide Hela 2-iodoacetamide Orbitrap Carboxymethylation Escherichia coli E. coli Ptm Kidney Protein glycation Hek293 Carboxymethyllysine Lc-ms/ms Age Nipcae Carbamidomethylation Advanced glycation end-product 
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